Martsevich S Iu, Metelitsa V I, Slastnikova I D, Simkhaev L S, Egorov L V, Blagodatskikh S V
Kardiologiia. 1990 Oct;30(10):44-6.
Repeated treadmill exercise tests were used in 20 patients with stable exercise-induced angina in order to comparatively examine various dosage forms of isosorbide-5-mononitrate (IMN) and isosorbide dinitrate (ID) during their single administration. The antianginal effect of conventional IMN tablets (Monisid, Bulgaria) lasted about 5 hours and 1-2 hours longer than that shown by long-acting tablets (Olicard, FRG) and lasted on an average of 12 hours. There was a correlation between the antianginal effect of IMN and its blood concentration. A significant individual variability was observed in the potency of all the dosage forms of IMN and ID under study. The dosage form of IMN had antianginal effects that were similar and even superior to those exhibited by ID.
对20例稳定型运动诱发心绞痛患者进行重复的跑步机运动试验，以便在单次给药期间比较5-单硝酸异山梨酯（IMN）和硝酸异山梨酯（ID）的各种剂型。传统IMN片剂（Monisid，保加利亚）的抗心绞痛作用持续约5小时，比长效片剂（Olicard，联邦德国）长1 - 2小时，平均持续12小时。IMN的抗心绞痛作用与其血药浓度之间存在相关性。在所研究的IMN和ID的所有剂型的效力方面观察到显著的个体差异。IMN的剂型具有与ID相似甚至优于ID的抗心绞痛作用。
