Frohn A, Weidle E G, Seelhorst A, Steuhl K P, Thiel H J
Abteilung I. Allgemeine Augenheilkunde mit Poliklinik, Universitäts-Augenklinik Tübingen.
Klin Monbl Augenheilkd. 1990 Nov;197(5):432-5. doi: 10.1055/s-2008-1046306.
The Hyperimmunoglobulinemia-E-Syndrome (HIE) is characterized by high levels of serum-IgE, diminished counts of T-suppressor-cells, eosinophilia, and disturbed chemotactic functions of neutrophil granulocytes. An 8 years old female, suffering from hyperimmunoglobulinemia E (HIE), showed marginal corneal ulcera since five years. Positive conjunctival smears included several bacterias and chlamydia, but never local herpes virus. Inspite of treatment by antibiotics, virostatica, and therapeutical contact lens, a spontaneous corneal perforation occurred. A penetrating keratoplasty was successful for a short time, but soon ulceration rose again. At last a second penetrating keratoplasty was necessary. The early status showed tidy results, but some weeks later marginal ulceration occurred again. There was no clinical proof for herpetical genesis of the course, but evidence is conceivable for pathomechanisms similar to conjunctivitis vernalis.
高免疫球蛋白E综合征（HIE）的特征是血清IgE水平升高、T抑制细胞计数减少、嗜酸性粒细胞增多以及中性粒细胞趋化功能紊乱。一名8岁患有高免疫球蛋白E（HIE）的女性，自5年前起出现边缘性角膜溃疡。结膜涂片阳性结果包括多种细菌和衣原体，但从未发现局部疱疹病毒。尽管使用了抗生素、抗病毒药物和治疗性隐形眼镜进行治疗，仍发生了自发性角膜穿孔。穿透性角膜移植术短期内取得了成功，但很快溃疡又复发了。最后不得不进行第二次穿透性角膜移植术。早期情况显示效果良好，但几周后边缘溃疡再次出现。病程中没有临床证据表明是疱疹性病因，但可以想象其发病机制与春季结膜炎相似。
