University of Vienna, Research Platform Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms, Althanstrasse 14, 1090 Vienna, Austria.
Int J Pharm. 2012 Nov 1;437(1-2):83-8. doi: 10.1016/j.ijpharm.2012.08.003. Epub 2012 Aug 8.
Nanocarriers are highly interesting delivery systems for the dermal application of drugs. Based on a eudermic alkylpolyglycosid nanoemulsions, solid lipid nanoparticles (SLN) and nano-structured lipid carriers (NLC) were prepared by ultrasonic dispersion. The ultrasound preparation technique turned out to be convenient and rapid. For reasons of comparison, nanoemulsions were also prepared by high-pressure homogenisation with highly similar physicochemical properties. Cryo electron microscopy was employed to elucidate the microstructure of the ultrasound-engineered nanocarriers. Furthermore, in vitro skin experiments showed excellent skin permeation and penetration properties for flufenamic acid from all formulations. Moreover, ATR-FTIR studies revealed barrier-restorative properties for NLC and SLN. Furthermore, the rheological characteristics of all nanocarriers were determined. In order to increase the viscosity, three different polymers were employed to also prepare semi-solid NLC drug delivery systems. All of them exhibited comparable skin diffusion properties, but may offer improved dermal applicability.
纳米载体是用于药物经皮应用的极具吸引力的递送系统。基于非水性烷基糖苷纳米乳剂，通过超声分散制备了固体脂质纳米粒（SLN）和纳米结构脂质载体（NLC）。超声制备技术简便快捷。出于比较的原因，也通过高压均质法制备了具有高度相似理化性质的纳米乳剂。冷冻电子显微镜用于阐明超声工程纳米载体的微观结构。此外，体外皮肤实验表明，所有制剂中氟芬那酸的皮肤渗透和穿透性能均优异。此外，ATR-FTIR 研究表明 NLC 和 SLN 具有屏障修复特性。此外，还确定了所有纳米载体的流变特性。为了增加粘度，还使用了三种不同的聚合物来制备半固体 NLC 药物递送系统。它们都表现出可比较的皮肤扩散性能，但可能提供更好的经皮适用性。
