School of Mechanical Engineering, Korea University, South Korea.
Lab Chip. 2012 Oct 21;12(20):3861-5. doi: 10.1039/c2lc40445a.
Spatiotemporal analysis of the inflammatory response has been limited by the difficulties of in vivo imaging and reconstitution of inflammation in vitro. Here, we present a novel method for establishing in vivo-like inflammatory models in a microfluidic device and quantitatively measuring the three-dimensional transmigration of neutrophils during the inflammatory process. This enabled us to concurrently characterize transendothelial migration behaviors of neutrophils under the influence of various inflammatory stimuli.
炎症反应的时空分析受到体内成像和体外炎症重建困难的限制。在这里，我们提出了一种在微流控装置中建立类似体内炎症模型的新方法，并定量测量了炎症过程中中性粒细胞的三维迁移。这使我们能够同时描述在各种炎症刺激下中性粒细胞跨内皮迁移行为。
