Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.
Department of Biological and Biomedical Sciences, Oakland University, Rochester, MI 48309, USA.
Curr Neuropharmacol. 2023;21(3):599-620. doi: 10.2174/1570159X20666220706112711.
The vascular system plays a critical role in human physiology and diseases. It is a complex subject to study using in vitro models due to its dynamic and three-dimensional microenvironment. Microfluidic technology has recently become a popular technology in various biological fields for its advantages in mimicking complex microenvironments to an extent not achievable by more conventional platforms. Microfluidic technologies can reproduce different vascular system-related structures and functions that can be utilized for drug development and human diseases studies. Herein, we first review the relevant structural and functional vascular biology systems of various organ systems and then the fabrication methods to reproduce these vascular districts. We provide a thorough review of the latest achievement in vascular organ-on-chip modeling specific to lung, heart, and the brain microvasculature for drug screening and the study of human disorders.
血管系统在人体生理学和疾病中起着至关重要的作用。由于其动态和三维微环境，使用体外模型研究这一系统具有挑战性。微流控技术最近在各种生物领域成为一种流行的技术，因为它具有模拟复杂微环境的优势，而这是更传统平台无法实现的。微流控技术可以复制不同的与血管系统相关的结构和功能，可用于药物开发和人类疾病研究。在此，我们首先综述了各种器官系统的相关结构和功能血管生物学系统，然后介绍了复制这些血管区域的制造方法。我们全面综述了用于药物筛选和人类疾病研究的肺、心脏和脑微血管的血管器官芯片建模方面的最新成果。
