Program in Integrative Biology, Florida Atlantic University, Boca Raton, FL, 33431, USA,
Amino Acids. 2014 Jan;46(1):31-46. doi: 10.1007/s00726-012-1382-z. Epub 2012 Aug 19.
In the present era, investigators seek to find therapeutic interventions that are multifaceted in their mode of action. Such targets provide the most advantageous routes for addressing the multiplicity of pathophysiological avenues that lead to neuronal dysfunction and death observed in neurological disorders and neurodegenerative diseases. Taurine, an endogenous amino acid, exhibits a plethora of physiological functions in the central nervous system. In this review, we describe the mode of action of taurine and its clinical application in the neurological diseases: Alzheimer's disease, Parkinson's disease and Huntington's disease.
在当今时代，研究人员寻求寻找具有多种作用模式的治疗干预措施。这些靶点为解决导致神经功能障碍和死亡的多种病理生理途径提供了最有利的途径，这些途径在神经紊乱和神经退行性疾病中都有观察到。牛磺酸是一种内源性氨基酸，在中枢神经系统中具有多种生理功能。在这篇综述中，我们描述了牛磺酸的作用模式及其在阿尔茨海默病、帕金森病和亨廷顿病等神经系统疾病中的临床应用。
