Shire Development LLC, Wayne, PA 19087, USA.
Am J Alzheimers Dis Other Demen. 2012 Nov;27(7):474-82. doi: 10.1177/1533317512456449. Epub 2012 Aug 16.
To validate the Caregiver-Perceived Burden Questionnaire (CPBQ) and report its psychometric properties.
The CPBQ was administered to caregivers of patients with moderate-to-severe AD in a double-blind randomized trial comparing extended-release memantine to placebo (n = 676). Measurement properties were analyzed using factor analysis, classical test theory, and Rasch analysis.
Two subscales were identified: the Caregivers' Assessment of the Patient (CAP) and the Caregivers' Assessment of Themselves (CAT). The reliability was .89 (CAP) and .83 (CAT). The CAP scores were significantly correlated (r > .3) with scores from the Severe Impairment Battery (SIB) and the Neuropsychiatric Inventory (NPI). The CAT scores were significantly correlated with NPI scores. The CAT discriminated among patients by clinician-rated severity and significantly differentiated between responders and nonresponders.
The CPBQ appears to be a reliable, valid, and responsive measure that enables linking caregiver's perceptions about burden and patient function in patients with moderate-to-severe AD.
验证照顾者感知负担问卷（CPBQ）并报告其心理测量学特性。
在一项比较缓释美金刚与安慰剂的双盲随机试验中，将 CPBQ 施用于中度至重度 AD 患者的照顾者（n = 676）。使用因子分析、经典测试理论和 Rasch 分析来分析测量特性。
确定了两个分量表：患者的照顾者评估（CAP）和照顾者的自我评估（CAT）。信度为.89（CAP）和.83（CAT）。CAP 评分与严重损伤量表（SIB）和神经精神问卷（NPI）的评分显著相关（r>.3）。CAT 评分与 NPI 评分显著相关。CAT 根据临床医生评定的严重程度对患者进行区分，并能显著区分应答者和无应答者。
CPBQ 似乎是一种可靠、有效且敏感的测量工具，能够将照顾者对中度至重度 AD 患者负担和患者功能的感知联系起来。
