Kulah A, Akar M, Baykut L
Neurosurgical Clinic of Dicle-University School of Medicine, Diyarbakir, Turkey.
Neurochirurgia (Stuttg). 1990 Nov;33(6):177-80. doi: 10.1055/s-2008-1053579.
The results of a prospective study on the effects of dimethyl sulfoxide (DMSO) in patients with severe closed head injuries causing brain edema and increase in intracranial pressure (ICP) are presented. 10 patients were selected and carefully analyzed according to Glasgow coma scale (GCS) scores and severity of brain edema. The results demonstrate that DMSO rapidly reduces the raised ICP, increases the cerebral perfusion pressure (CPP) and improves the neurological course and outcome without affecting the systemic blood pressure and patient responsiveness except only in one patient. We also point out that the rebound effect does not occur.
本文介绍了一项关于二甲基亚砜（DMSO）对严重闭合性颅脑损伤导致脑水肿和颅内压（ICP）升高患者影响的前瞻性研究结果。根据格拉斯哥昏迷量表（GCS）评分和脑水肿严重程度选择了10例患者并进行了仔细分析。结果表明，DMSO能迅速降低升高的ICP，增加脑灌注压（CPP），并改善神经病程和预后，除1例患者外，不影响全身血压和患者反应性。我们还指出，不会出现反弹效应。
