Ramoo S
University of Melbourne Veterinary Clinic and Hospital, Werribee, Australia.
N Z Vet J. 2013 Jan;61(1):45-8. doi: 10.1080/00480169.2012.700628. Epub 2012 Aug 21.
A 16-year-old dog was presented to the University of Melbourne Veterinary Clinic and Hospital for dyspnoea and tachypnoea, which had been occurring over the previous 48 h prior to presentation.
Physical examination findings included marked wheezing and inspiratory noises on thoracic auscultation. Diagnostic tests performed revealed a large pulmonary mass, the presence of hypertrophic osteopathy in the forelimbs and an abnormal myocardium. The patient continued to deteriorate while in hospital, and was euthanased at the owner's request. A post-mortem examination was carried out, which revealed the presence of two separate pulmonary masses, one of which was completely occluding the mainstem bronchus.
One tumour was histologically classified as an adenocarcinoma, the other as an extraskeletal osteosarcoma. The osteosarcoma had metastasised to the myocardium, spleen and kidneys. The forelimb changes were consistent with hypertrophic osteopathy.
This is the first reported case of two separate pulmonary masses in a dog, one of which metastasised to the myocardium. Hypertrophic osteopathy is a common pathological condition associated with a broad spectrum of diseases. The aim of this case report is to highlight the condition and remind clinicians of its relatively common incidence, as well as to prompt clinicians to look for underlying pathology. The current understanding of the pathophysiology of hypertrophic osteopathy is also discussed.
一只16岁的犬被送至墨尔本大学兽医诊所及医院，出现呼吸困难和呼吸急促症状，这些症状在就诊前的48小时内一直存在。
体格检查发现包括胸部听诊时有明显的哮鸣音和吸气性杂音。所进行的诊断测试显示有一个大的肺部肿块、前肢存在肥大性骨关节病以及心肌异常。该患者在住院期间病情持续恶化，应主人要求实施了安乐死。进行了尸检，结果显示存在两个独立的肺部肿块，其中一个完全阻塞了主支气管。
一个肿瘤经组织学分类为腺癌，另一个为骨外骨肉瘤。骨肉瘤已转移至心肌、脾脏和肾脏。前肢的变化与肥大性骨关节病相符。
这是首例报道的犬出现两个独立肺部肿块且其中一个转移至心肌的病例。肥大性骨关节病是一种与多种疾病相关的常见病理状况。本病例报告的目的是突出这种情况并提醒临床医生其相对常见的发生率，同时促使临床医生寻找潜在的病理学原因。还讨论了目前对肥大性骨关节病病理生理学的认识。
