Hahn K A, Richardson R C
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-7403.
J Am Vet Med Assoc. 1989 Aug 1;195(3):351-3.
Cisplatin (cis-diammine-dichloroplatinum) treatment induced partial remission of pulmonary metastatic malignant mesenchymoma and nearly complete radiographic remission of hypertrophic osteopathy in a 14-year-old Beagle. Cisplatin was given once every 3 weeks. Clinical signs of hypertrophic osteopathy resolved one week after initiation of treatment. Partial remission of pulmonary metastases and partial radiographic remission of hypertrophic osteopathy was seen 6 weeks after initiation of treatment. Previous treatment of neoplasia-related hypertrophic osteopathy has consisted of removal of the initiating mass or vagotomy. In this case, appropriate chemotherapy was used to control clinical signs and progression of hypertrophic osteopathy.
顺铂（顺二氨二氯铂）治疗使一只14岁的比格犬肺部转移性恶性间叶瘤部分缓解，肥大性骨关节病的影像学表现几乎完全缓解。顺铂每3周给药一次。肥大性骨关节病的临床症状在治疗开始后一周消失。治疗开始6周后，肺部转移灶部分缓解，肥大性骨关节病的影像学表现部分缓解。以往对肿瘤相关性肥大性骨关节病的治疗包括切除原发肿块或迷走神经切断术。在本病例中，采用了适当的化疗来控制肥大性骨关节病的临床症状和进展。
