Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.
Pediatr Rheumatol Online J. 2012 Aug 20;10(1):25. doi: 10.1186/1546-0096-10-25.
As patients with juvenile idiopathic arthritis (JIA) progress into adulthood, long-term outcome is determined by disease activity, physical and psychosocial development. Decreased aerobic capacity may play a critical role in health-related outcomes in JIA, since it has been linked with cardiovascular morbidity and mortality in late adulthood. The objectives of the current study are to examine the aerobic capacity and its relation to parameters of disease activity in children, adolescents and young adults with JIA.
Sixty-three patients with JIA (aged 10-27 years) were cross sectional studied regarding their aerobic capacity and correlations were made to demographic, disease-related variables, and medication utilization. in a cross-sectional study group of 63 patients of all subtypes. Patients were divided in three age groups, 10-13 years; 14-17 years and 18-27 years.
Reduced aerobic capacity is found in clinical remission as well as active disease in all subtypes and all age groups. Aerobic capacity is more impaired in active disease shown by DAS 28, JADAS 27, ESR and serum thrombocyte counts. Lower haemoglobin has a negative impact. Long-term used medication including methotrexate and corticosteroids didn't influence outcome. There is no association with current sports participation.
Reduced aerobic capacity is present in adolescents and young adults with JIA, both in active disease and in patients with remission. Measures of aerobic capacity may serve as important outcome measure in JIA.
随着幼年特发性关节炎（JIA）患者进入成年期，长期预后取决于疾病活动度、身体和心理社会发育。有氧运动能力下降可能在 JIA 的健康相关结局中起关键作用，因为它与成年后期的心血管发病率和死亡率有关。本研究的目的是检查 JIA 患儿、青少年和年轻成人的有氧运动能力及其与疾病活动参数的关系。
对 63 例 JIA 患者（年龄 10-27 岁）进行了横断面研究，评估其有氧运动能力，并与人口统计学、疾病相关变量和药物使用情况进行相关性分析。在一个横断面研究组的 63 例所有亚型的患者中。患者分为三组，年龄分别为 10-13 岁、14-17 岁和 18-27 岁。
在所有亚型和所有年龄组中，临床缓解期和活动期均存在有氧运动能力下降。DAS28、JADAS27、ESR 和血清血小板计数显示活动期疾病的有氧运动能力下降更明显。较低的血红蛋白水平会产生负面影响。长期使用的药物，包括甲氨蝶呤和皮质类固醇，对结果没有影响。目前的运动参与与疾病无相关性。
在患有 JIA 的青少年和年轻成人中，无论是在活动期疾病还是在缓解期患者中，都存在有氧运动能力下降。有氧运动能力的测量值可能是 JIA 的一个重要的预后指标。
