载脂蛋白A5基因多态性与代谢综合征风险：一项荟萃分析。
Apolipoprotein a5 gene polymorphism and risk for metabolic syndrome: a meta-analysis.
作者信息
Liu Cun-Fei, Yang Qun-Fang, Chen Xing-Lin, Liu Cheng-Yun
机构信息
Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
出版信息
Genet Test Mol Biomarkers. 2012 Oct;16(10):1241-5. doi: 10.1089/gtmb.2012.0183. Epub 2012 Aug 20.
BACKGROUND
Many studies have focused on the association between the apolipoprotein A5 (ApoA5) polymorphism and the risk of metabolic syndrome (MetS). However, these studies drew inconsistent conclusions. The aim of this study was to evaluate the exact association between the ApoA5 polymorphism and MetS in a large-scale meta-analysis.
METHODS
The PubMed, Embase, and Science Citation Index (ISI Web of Science) databases were searched to collect all publications on the association between the ApoA5 polymorphism and MetS. Two common variants of ApoA5 (namely -1131T>C in the promoter region and c.56C>G in the coding region) with the risk of MetS were analyzed. The overall odd ratios (ORs) and 95% confidence intervals (CIs) for -1131T>C (CC+TC) versus TT genotype and c.C56G (GG+GC) versus CC were assessed between the MetS and control group. Subgroup analysis was further performed by ethnicity. The meta-analysis was performed by Stata11.0.
RESULTS
Twelve studies from 10 publications were chosen in our meta-analysis. The combined results showed that C allele carriers (CC+TC) of -1131T>C had a significantly higher risk of MetS for the overall (OR=1.32; 95% CI: 1.14-1.53; p=0.000) with moderate heterogeneity (I2=54.9%, p=0.014). Subgroup analysis was further performed according to ethnicity, and the association was still significant in Asians (OR=1.42; 95% CI: 1.25-1.62; p=0.000), but not in white populations (OR=1.25; 95% CI: 0.97-1.61; p=0.087). When analyzing the association between c.C56G and MetS, the G allele carrier (GG+GC) genotype significantly increased the risk of MetS (OR=1.32; 95% CI: 1.15-1.50; p=0.000) in white populations. No significant publication bias was observed in either -1131T>C or c.C56G.
CONCLUSIONS
Our study suggested that the ApoA5 -1131T>C polymorphism was significantly associated with the risk of MetS in Asians, but not in white populations. However, the c.C56G polymorphism was significantly associated with MetS in white populations.
背景
许多研究聚焦于载脂蛋白A5（ApoA5）基因多态性与代谢综合征（MetS）风险之间的关联。然而，这些研究得出了不一致的结论。本研究的目的是通过大规模荟萃分析评估ApoA5基因多态性与MetS之间的确切关联。
方法
检索PubMed、Embase和科学引文索引（科学网）数据库，以收集所有关于ApoA5基因多态性与MetS关联的出版物。分析了ApoA5的两个常见变体（即启动子区域的-1131T>C和编码区域的c.56C>G）与MetS风险的关系。评估了MetS组和对照组之间-1131T>C（CC+TC）与TT基因型以及c.C56G（GG+GC）与CC的总体比值比（OR）和95%置信区间（CI）。进一步按种族进行亚组分析。使用Stata11.0进行荟萃分析。
结果
本荟萃分析纳入了来自10篇出版物的12项研究合并结果显示，-1131T>C的C等位基因携带者（CC+TC）患MetS的总体风险显著更高（OR=1.32；95%CI：1.14-1.53；p=0.000），异质性中等（I2=54.9%；p=0.014）。根据种族进一步进行亚组分析，在亚洲人中这种关联仍然显著（OR=1.42；95%CI：1.25-1.62；p=0.000），但在白种人群中不显著（OR=1.25；95%CI：0.97-1.61；p=0.087）。在分析c.C56G与MetS的关联时，白种人群中G等位基因携带者（GG+GC）基因型显著增加了患MetS的风险（OR=1.32；95%CI：1.15-1.50；p=0.000）。在-1131T>C或c.C56G中均未观察到显著的发表偏倚。
结论
我们的研究表明，ApoA5 -1131T>C基因多态性在亚洲人中与MetS风险显著相关，但在白种人群中并非如此。然而，c.C56G基因多态性在白种人群中与MetS显著相关。
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