Rasmussen Finn, Hancox Robert J, Nair Parameswaran, Hansen Henrik Steen, Siersted Hans Christian, Nybo Mads
Department of Allergy and Respiratory Medicine, Near East University Hospital, Lefcosia, Turkey.
Clin Respir J. 2013 Jul;7(3):268-75. doi: 10.1111/crj.12000. Epub 2012 Oct 12.
Epidemiological data have linked obesity with an increased risk of asthma, but the mechanisms responsible for this relationship remain unknown. One possible mechanism, which has received little attention, could be the effect of cholesterol metabolism on airway smooth muscle function. The present study investigated the association between airway hyperresponsiveness (AHR) to methacholine and body mass index (BMI) and plasma lipoproteins [low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol].
Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years.
In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR at age 20 in both sexes (P < 0.05). HDL, LDL/HDL ratio and total cholesterol were not associated with AHR. In multiple regression analyses adjusted for sex, lung function, smoking and asthma, only higher levels of BMI at age 14 or 20 years were significantly associated with increased AHR at age 20 years, while neither LDL, HDL and LDL/HDL ratio nor total cholesterol were significantly associated with AHR.
We confirmed that in teenagers there is a strong association between BMI and AHR to methacholine. This association seems to be independent of the plasma lipoprotein levels at that age.
流行病学数据表明肥胖与哮喘风险增加有关，但这种关系的潜在机制尚不清楚。一种可能的机制，即胆固醇代谢对气道平滑肌功能的影响，却很少受到关注。本研究调查了对乙酰甲胆碱的气道高反应性（AHR）与体重指数（BMI）及血浆脂蛋白[低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和总胆固醇]之间的关联。
在一个基于人群的队列中评估了14岁和20岁时AHR、BMI与血浆脂蛋白之间的关联。
在未经调整的分析中，14岁时较高的LDL胆固醇水平与20岁时男女两性的AHR均相关（P < 0.05）。HDL、LDL/HDL比值和总胆固醇与AHR无关。在对性别、肺功能、吸烟和哮喘进行调整的多元回归分析中，仅14岁或20岁时较高的BMI水平与20岁时AHR增加显著相关，而LDL、HDL和LDL/HDL比值以及总胆固醇均与AHR无显著关联。
我们证实，在青少年中，BMI与对乙酰甲胆碱的AHR之间存在密切关联。这种关联似乎独立于该年龄段的血浆脂蛋白水平。
