Department of Ophthalmology, First People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University, Shanghai, China.
Curr Eye Res. 2013 Jan;38(1):168-73. doi: 10.3109/02713683.2012.713150. Epub 2012 Aug 20.
To investigate macular pigment optical density (MPOD) and its relationship with refractive status and foveal thickness in Chinese school-aged children.
Ninety-four healthy Chinese children, 6 to 12 years old, were recruited to the study. MPOD was measured with a heterochromatic flicker photometer (HFP), and foveal thickness, including both minimum and central foveal thicknesses (MFT and CFT, respectively), were measured by optical coherence tomography (OCT) with fast macular map scan. A noncontact tonometer was used to measure intraocular pressure (IOP) followed by determination of the refraction using an autorefractor after cycloplegia. Information on body mass index (BMI) was obtained. The correlation between MPOD values and foveal thickness, spherical equivalent (SE) refraction, IOP, BMI, sex, and age was statistically analyzed using SAS 8.2 statistical software.
The MPOD in examined school-aged children was 0.56 ± 0.25, without any significant difference between boys and girls (p = 0.12). MPOD showed no significant association with age, BMI, IOP, SE, MFT, or CFT. In the myopia group, however, there was an inverse relationship between MPOD and MFT (R =-0.66, p = 0.028) and a positive relationship between MPOD and CFT (R = 0.67, p = 0.025).
MPOD was inversely related to MFT and positively related to CFT in Chinese school-age children with low-to-moderate myopia. MPOD showed no significant association with age, BMI, IOP, SE or foveal thickness.
研究中国学龄儿童的黄斑色素光学密度（MPOD）及其与屈光状态和中心凹厚度的关系。
本研究共纳入 94 名 6 至 12 岁的健康中国儿童。使用对比闪光视光度计（HFP）测量 MPOD，使用快速黄斑图谱扫描的光学相干断层扫描（OCT）测量中心凹最小和中心厚度（MFT 和 CFT）。使用非接触眼压计（NCT）测量眼压（IOP），散瞳后使用自动屈光仪（AR）测量屈光度。记录体质量指数（BMI）信息。使用 SAS 8.2 统计软件对 MPOD 值与中心凹厚度、等效球镜（SE）屈光度、IOP、BMI、性别和年龄的相关性进行统计分析。
研究中检查的学龄儿童的 MPOD 为 0.56±0.25，男女性别之间无显著差异（p = 0.12）。MPOD 与年龄、BMI、IOP、SE、MFT 或 CFT 均无显著相关性。然而，在近视组中，MPOD 与 MFT 呈负相关（R =-0.66，p = 0.028），与 CFT 呈正相关（R = 0.67，p = 0.025）。
在中国低度至中度近视的学龄儿童中，MPOD 与 MFT 呈负相关，与 CFT 呈正相关。MPOD 与年龄、BMI、IOP、SE 或中心凹厚度无显著相关性。
