Piot O, Betschart J, Stutzmann J M, Blanchard J C
Rhône-Poulenc Santé, Centre de Recherches de Vitry-Alfortville, Vitry sur Seine, France.
Neurosci Lett. 1990 Sep 4;117(1-2):140-3. doi: 10.1016/0304-3940(90)90133-t.
In a model of physical dependence in mice, treatment with cyclopyrrolones such as zopiclone and suriclone (from 4 to 400 mg/kg/day), did not modify the sensitivity of the gamma-aminobutyric acid (GABA) receptor complex to the partial inverse agonist FG 7142 following their withdrawal, whereas sensitivity changes were observed after treatment and withdrawal from some benzodiazepines (e.g. lorazepam, diazepam, flunitrazepam and triazolam). These data suggest that, in contrast to some benzodiazepines, zopiclone and suriclone may not produce physical dependence.
在小鼠身体依赖性模型中，使用诸如佐匹克隆和舒立克隆等环吡咯酮（剂量为4至400毫克/千克/天）进行治疗，在撤药后并未改变γ-氨基丁酸（GABA）受体复合物对部分反向激动剂FG 7142的敏感性，而在使用某些苯二氮䓬类药物（如劳拉西泮、地西泮、氟硝西泮和三唑仑）治疗并撤药后则观察到了敏感性变化。这些数据表明，与某些苯二氮䓬类药物不同，佐匹克隆和舒立克隆可能不会产生身体依赖性。
