大鼠体内因神经生长因子抑制而改变的雪旺细胞与神经元相互作用的恢复情况

In vivo recovery of Schwann cell-neuronal interactions altered by nerve growth factor suppression in the rat.

作者信息

Urschel B A, Hulsebosch C E

机构信息

Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston 77550-2772.

出版信息

Neurosci Lett. 1990 Sep 4;117(1-2):50-5. doi: 10.1016/0304-3940(90)90118-s.

DOI:10.1016/0304-3940(90)90118-s

PMID:2290621

Abstract

Recovery of Schwann cell-neuronal interactions altered by suppression of endogenous nerve growth factor (NGF) with antibodies to NGF (anti-NGF) was determined by morphometric analysis of unmyelinated and myelinated sensory fibers in the T9 dorsal roots in 3 groups of animals: (1) rats one week after cessation of anti-NGF treatment (anti-NGF + 1WK), (2) rats given antibodies to NGF (anti-NGF) and (3) untreated same age littermates (UNTR). The results indicate that (1) recovery of normal myelination begins within one week of cessation of anti-NGF treatment for small caliber fibers and (2) the observed results of anti-NGF treatment on Schwann cell-neuronal interactions were due to anti-NGF treatment and were not an indirect effect of a general diseased state.

摘要

通过对3组动物T9背根中无髓鞘和有髓鞘感觉纤维进行形态计量分析，确定了用抗神经生长因子（NGF）抗体（抗NGF）抑制内源性神经生长因子（NGF）后雪旺细胞 - 神经元相互作用的恢复情况：（1）抗NGF治疗停止一周后的大鼠（抗NGF + 1WK），（2）给予抗NGF抗体的大鼠（抗NGF），以及（3）未治疗的同年龄同窝仔鼠（未处理）。结果表明：（1）对于小口径纤维，抗NGF治疗停止一周内正常髓鞘形成开始恢复；（2）抗NGF治疗对雪旺细胞 - 神经元相互作用的观察结果是由于抗NGF治疗，而非一般疾病状态的间接影响。