Division of Respirology, Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung, Taiwan.
Respir Care. 2013 Apr;58(4):614-22. doi: 10.4187/respcare.01691.
To assess whether high-resolution computed tomography (HRCT) variables are as good as other known clinical variables in grading emphysema patients.
A detailed clinical history was taken and physical examination performed. We performed serum study, lung function testing, and HRCT scanning to assess emphysema. Mean lung density, the attenuation value separating the least 15% of pixels (PERC15), the percentage of the relative area of the lungs with attenuation values < -950 Hounsfield units (HU) (RA950), and histogram analysis were calculated from computerized data.
The final analysis was based on data from 92 subjects, and they were moderately emphysematous (mean lung density was -877 ± 23 HU, PERC15 was -953 ± 21 HU, and RA950 was 16 ± 5%). There was a significant difference regarding subjective emphysema severity in the St George's Respiratory Questionnaire, smoking history, FEV1, C-reactive protein, age, and body mass index (P < .001). There was a significant correlation between the 3 objective image variables and the 6 objective clinical variables (St George's Respiratory Questionnaire, smoking history, FEV1, C-reactive protein, age, and body mass index) (P < .001).
This study shows the possible important role of HRCT in the diagnosis and quantification of pulmonary emphysema.
评估高分辨率计算机断层扫描（HRCT）变量在肺气肿患者分级中的表现是否与其他已知的临床变量一样好。
详细采集病史并进行体格检查。我们进行了血清学研究、肺功能测试和 HRCT 扫描，以评估肺气肿。从计算机数据中计算平均肺密度、分离最少 15%像素的衰减值（PERC15）、衰减值< -950 亨氏单位（HU）的相对肺面积百分比（RA950）和直方图分析。
最终分析基于 92 名受试者的数据，他们的肺气肿程度为中度（平均肺密度为-877 ± 23 HU，PERC15 为-953 ± 21 HU，RA950 为 16 ± 5%）。圣乔治呼吸问卷的主观肺气肿严重程度、吸烟史、FEV1、C 反应蛋白、年龄和体重指数存在显著差异（P <.001）。3 个客观图像变量与 6 个客观临床变量（圣乔治呼吸问卷、吸烟史、FEV1、C 反应蛋白、年龄和体重指数）之间存在显著相关性（P <.001）。
本研究表明 HRCT 在诊断和量化肺肺气肿方面可能具有重要作用。
