Zhao K, Luo Y-Z, Zhou S-H, Dai B-L, Luo X-M, Yan S-X, Wang Q-Y, Ling L
PET Centre, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
J Int Med Res. 2012;40(3):1192-206. doi: 10.1177/147323001204000340.
Laryngeal mucosa-associated lymphoid tissue (MALT) lymphoma is rare, with only 25 cases reported in the literature. This report presents a case of laryngeal MALT lymphoma in a 35-year-old female with a 6-year history of progressively worsening hoarseness. MALT lymphoma was diagnosed based on biopsy and immunohistochemical analysis. The patient received two cycles of cyclophosphamide + epirubicin + vincristine + prednisone (CHOP) chemo therapy, which was ineffective. (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) showed (18)F-FDG accumulation in the larynx only and identified stage IE lymphoma. CHOP chemotherapy was terminated and the patient was treated with radiotherapy. After 3 months (total radiation dose 27 Gy), (18)F-FDG PET/CT scan showed that the laryngeal lesion was in complete remission. A review of the literature on the MEDLINE(®)/PubMed(®) databases regarding laryngeal MALT lymphoma and the use of PET/CT found that radiotherapy is the first-line treatment for stage I and II MALT lymphoma.
喉黏膜相关淋巴组织（MALT）淋巴瘤较为罕见，文献中仅报道过25例。本报告介绍了一名35岁女性喉MALT淋巴瘤病例，该患者有6年渐进性声音嘶哑病史。MALT淋巴瘤通过活检和免疫组化分析确诊。患者接受了两个周期的环磷酰胺+表柔比星+长春新碱+泼尼松（CHOP）化疗，但无效。（18）F-氟脱氧葡萄糖（（18）F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）显示仅喉部有（18）F-FDG积聚，并确定为IE期淋巴瘤。CHOP化疗终止，患者接受放疗。3个月后（总辐射剂量27 Gy），（18）F-FDG PET/CT扫描显示喉部病变完全缓解。对MEDLINE（®）/PubMed（®）数据库中有关喉MALT淋巴瘤及PET/CT应用的文献进行回顾发现，放疗是I期和II期MALT淋巴瘤的一线治疗方法。
