Department of Laboratory Medicine/Clinical Chemistry, Örebro University, Sweden.
Arch Gerontol Geriatr. 2013 Mar-Apr;56(2):303-8. doi: 10.1016/j.archger.2012.07.009. Epub 2012 Aug 18.
Well-being (WB) is a complex variable in its relation to physical health and other personal and social characteristics. The aim was to study subjective well-being (SWB) and its possible associations with traditional biomarkers of cardiovascular risk or dementia, in Swedish seniors. SWB was estimated by the Psychological General Well-Being (PGWB) index in two study groups. The active seniors (AS) group consisted of community-dwelling elderly Swedes leading an active life (n=389). The DGM cohort (n=300) consisted of subjects referred to the Memory Unit at the Department of Geriatrics, the cognitive problems had to be subjective, mild or moderate (MMSE≥10). There were differences in all six subdimensions of SWB or distress, and in the sum of PGWB scores, between the two study groups (p<0.001 for all), and adjustment for differences in biomarkers of somatic health (age, sex, blood pressure, BMI, HDL cholesterol, ApoB/ApoA1 ratio, creatinine, and homocysteine) did not attenuate these differences. In addition, cognition as assessed by the Clock-Drawing Test (CDT) showed independent associations with four of the PGWB subdimensions and with the PGWB sum. Among the subjects in the DGM cohort, SWB was equally low among subjects with an MCI (minor cognitive impairment) diagnosis or without a dementia diagnosis as among subjects diagnosed with dementia disorder. We conclude that the nosological grouping variable (AS vs. DGM cohort) and a cognitive factor were the main independent predictors of SWB in this sample of elderly Swedes, whereas biomarkers of somatic health played a subordinated role.
幸福感（WB）与其与身体健康和其他个人和社会特征的关系是一个复杂的变量。目的是研究主观幸福感（SWB）及其与心血管风险或痴呆的传统生物标志物的可能关联，在瑞典老年人中。SWB 通过心理一般幸福感（PGWB）指数在两个研究组中进行评估。积极的老年人（AS）组由生活活跃的社区居住的瑞典老年人组成（n=389）。DGM 队列（n=300）由认知问题必须是主观的、轻度或中度（MMSE≥10）的被转诊到老年病科记忆单元的受试者组成。在两个研究组之间，SWB 或痛苦的所有六个子维度以及 PGWB 评分的总和存在差异（所有 p<0.001），并且对躯体健康生物标志物（年龄、性别、血压、BMI、HDL 胆固醇、ApoB/ApoA1 比值、肌酐和同型半胱氨酸）差异的调整并没有减弱这些差异。此外，时钟绘制测试（CDT）评估的认知与 PGWB 的四个子维度以及 PGWB 总和独立相关。在 DGM 队列中的受试者中，MCI（轻度认知障碍）诊断或没有痴呆诊断的受试者的 SWB 与被诊断为痴呆障碍的受试者的 SWB 一样低。我们得出结论，在这个瑞典老年人样本中，分类变量（AS 与 DGM 队列）和认知因素是 SWB 的主要独立预测因素，而躯体健康的生物标志物则起次要作用。
