Religa Agnieszka A, Waters Andrew P
Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK.
Mol Biochem Parasitol. 2012 Oct;185(2):71-88. doi: 10.1016/j.molbiopara.2012.08.003. Epub 2012 Aug 10.
The SIR2 family of NAD(+)-dependent protein deacetylases, collectively called sirtuins, has been of central interest due to their proposed roles in life-span regulation and ageing. Sirtuins are one group of environment sensors of a cell interpreting external information and orchestrating internal responses at the sub-cellular level, through participation in gene regulation mechanisms. Remarkably conserved across all kingdoms of life SIR2 proteins in several protozoan parasites appear to have both conserved and intriguing unique functions. This review summarises our current knowledge of the members of the sirtuin families in Apicomplexa, including Plasmodium, and other protozoan parasites such as Trypanosoma and Leishmania. The wide diversity of processes regulated by SIR2 proteins makes them targets worthy of exploitation in anti-parasitic therapies.
NAD⁺依赖性蛋白脱乙酰酶的SIR2家族，统称为沉默调节蛋白，因其在寿命调节和衰老中所起的作用而备受关注。沉默调节蛋白是细胞的一组环境传感器，通过参与基因调控机制，在亚细胞水平上解读外部信息并协调内部反应。在所有生命王国中都非常保守的SIR2蛋白，在几种原生动物寄生虫中似乎具有保守且有趣的独特功能。本综述总结了我们目前对顶复门（包括疟原虫）以及其他原生动物寄生虫（如锥虫和利什曼原虫）中沉默调节蛋白家族成员的了解。SIR2蛋白调节的过程具有广泛多样性，这使其成为抗寄生虫治疗中值得开发的靶点。
