Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Mannheim, Germany.
Eur Neurol. 2012;68(3):162-5. doi: 10.1159/000339945. Epub 2012 Aug 14.
Large artery atherosclerosis (LAA) and small vessel disease (SVD) share common risk factors for stroke. We aimed at investigating the association of SVD with cerebral LAA as well as with atherosclerosis in patients with stroke likely to originate from aortic plaques.
We investigated 71 consecutive patients (48 men, mean age 64.2 ± 13 years) with ischemic stroke of undetermined cause according to the ASCO classification, who received ECG-triggered CT angiography for best available atherosclerotic plaque detection in the aorta.
Aortic atherosclerotic plaques were detected in 54 patients (76.1%). The presence of SVD significantly correlated with the presence of aortic plaques (p < 0.001), as well as LAA (p < 0.001) and risk factors such as arterial hypertension (p = 0.032) and diabetes mellitus (p = 0.017).
Aortic plaques are common in patients with stroke of undetermined cause. If so, SVD and LAA are often coexisting, which demonstrates the close link of macro- and microangiopathy, at least in cases of severe risk factors of atherosclerosis.
大动脉粥样硬化（LAA）和小血管疾病（SVD）与中风的共同危险因素。我们旨在研究 SVD 与大脑 LAA 以及可能起源于主动脉斑块的中风患者的动脉粥样硬化之间的关联。
我们调查了 71 例连续的（48 名男性，平均年龄 64.2±13 岁）根据 ASCO 分类确定为不明原因缺血性中风的患者，他们接受 ECG 触发 CT 血管造影以最佳检测主动脉中的动脉粥样硬化斑块。
54 例患者（76.1%）检测到主动脉粥样硬化斑块。SVD 的存在与主动脉斑块的存在显著相关（p<0.001），与 LAA 以及动脉高血压（p=0.032）和糖尿病（p=0.017）等危险因素也显著相关。
不明原因中风患者中主动脉斑块很常见。如果是这样，SVD 和 LAA 通常同时存在，这至少表明在严重动脉粥样硬化危险因素的情况下，大血管和小血管疾病之间存在密切联系。
