Department of Neurology, Shanghai Traditional Chinese and Western Medicine Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Stroke Vasc Neurol. 2020 Jun;5(2):198-204. doi: 10.1136/svn-2019-000289. Epub 2020 Mar 5.
Bilirubin, a product of heme metabolism, is the most potent endogenous antioxidant which increases in many oxidative stress conditions such as stroke. It has been widely known to exert neuroprotective effect on stroke through mechanisms involved in development, therefore, it can influence the occurrence and prognosis of ischaemic stroke (IS). In this review, studies were identified by a comprehensive search of Pubmed, Embase, the Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Methodology Register) and Web of Science to examine the correlation between serum bilirubin levels and risks of developing IS as well as IS outcomes. Additional studies were identified by reviewing references and contacting authors.
胆红素是血红素代谢的产物，是最有效的内源性抗氧化剂，在许多氧化应激条件下都会增加，如中风。它通过参与中风发展的机制对中风具有神经保护作用，因此，它可以影响缺血性中风（IS）的发生和预后。在本综述中，通过全面检索 Pubmed、Embase、Cochrane 图书馆（Cochrane 系统评价数据库、Cochrane 对照试验中心注册库（CENTRAL）、Cochrane 方法学登记册）和 Web of Science，确定了研究，以检查血清胆红素水平与发生 IS 以及 IS 结局的风险之间的相关性。通过查阅参考文献和联系作者，确定了其他研究。
