Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, São Paulo, 13083-970, Brazil.
Muscle Nerve. 2012 Sep;46(3):400-6. doi: 10.1002/mus.23331.
We examined whether doxycycline, an antibiotic member of the tetracycline family, improves the histopathology and muscle function in mdx mice, the experimental model of DMD.
Doxycycline was administered for 36 days (starting on postnatal day 0) and for 9 months (starting at 8 months of age) in drinking water. Histopathological, biochemical (creatine kinase), and functional (forelimb muscle grip strength) parameters were evaluated in limb, diaphragm, and cardiac muscle.
Doxycycline significantly minimized the dystrophic phenotype of skeletal and cardiac muscles and improved forelimb muscle strength. The drug protected muscle fibers against myonecrosis and reduced inflammation. Furthermore, it slowed the progression of myocardial fibrosis.
This study provides evidence that doxycycline may be a potential therapeutic agent for DMD.
我们研究了抗生素四环素类的多西环素是否能改善 DMD 实验模型 mdx 小鼠的组织病理学和肌肉功能。
多西环素通过饮用水给药 36 天（从出生后第 0 天开始）和 9 个月（从 8 月龄开始）。对四肢、膈肌和心肌的组织病理学、生化（肌酸激酶）和功能（前肢肌肉握力）参数进行评估。
多西环素显著减轻了骨骼肌和心肌的营养不良表型，并改善了前肢肌肉力量。该药物保护肌肉纤维免受肌坏死，并减少炎症。此外，它还减缓了心肌纤维化的进展。
本研究提供了证据表明多西环素可能是 DMD 的一种潜在治疗药物。
