University of Hawaii Cancer Center, 1236 Lauhala Street, Honolulu, HI 96813, USA.
Cancer Causes Control. 2012 Oct;23(10):1693-703. doi: 10.1007/s10552-012-0048-1. Epub 2012 Aug 21.
Composition of dietary fatty acid intake, which influences cytokine production, may contribute to the development of non-Hodgkin's lymphoma (NHL). Serum lipid levels may serve as biomarkers of inflammation associated with NHL risk.
We conducted a case-control analysis (275 cases and 549 controls) nested within the Multiethnic Cohort Study (whites, Japanese Americans, Latinos, African Americans, and Native Hawaiians) to examine the association of prediagnostic, erythrocyte membrane phospholipid fatty acid composition, and serum cholesterol and triglyceride (TG) concentrations with the risk of NHL. Conditional logistic regression was used to calculate odds ratios (OR) and 95 % confidence intervals (CI) by tertiles of biomarker concentrations.
Higher total saturated fatty acids (SFA) were associated with an increase in NHL risk (OR(T3 vs. T1) = 1.57 [95 % CI: 1.03-2.39]; p(trend) = 0.01), whereas no associations were detected for total n-3 or n-6 polyunsaturated fatty acids. Inverse associations were observed for total cholesterol (TC; OR (T3 vs. T1) = 0.51 [95 % CI: 0.35-0.74]; p(trend) < 0.0001) and high-density lipoprotein cholesterol (HDL-C; OR (T3 vs. T1) = 0.47 [95 % CI: 0.31-0.71]; p(trend) = 0.0001) but not for low-density lipoprotein cholesterol or TG. Adjustment for the use of lipid-lowering medication did not modify the results substantially.
This prospective biomarker investigation offers supportive evidence for an adverse effect of higher erythrocyte membrane SFA levels on NHL risk, but preclinical effects cannot be excluded. Inverse relations between prediagnostic, circulating TC and HDL-C and NHL risk may be due to reverse causation or a result of protective actions of these lipids and lipoproteins.
饮食中脂肪酸的组成会影响细胞因子的产生，从而可能导致非霍奇金淋巴瘤（NHL）的发生。血清脂质水平可能是与 NHL 风险相关的炎症的生物标志物。
我们在多民族队列研究（白人、日裔美国人、拉丁裔、非裔美国人和夏威夷原住民）中进行了病例对照分析（275 例病例和 549 例对照），以研究诊断前红细胞膜磷脂脂肪酸组成以及血清胆固醇和甘油三酯（TG）浓度与 NHL 风险的关系。采用条件 logistic 回归计算按生物标志物浓度三分位的比值比（OR）和 95%置信区间（CI）。
总饱和脂肪酸（SFA）水平越高，NHL 风险越高（OR（T3 与 T1）=1.57[95%CI：1.03-2.39]；p（趋势）=0.01），而总 n-3 或 n-6 多不饱和脂肪酸与 NHL 风险无关。总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）呈负相关（OR（T3 与 T1）=0.51[95%CI：0.35-0.74]；p（趋势）<0.0001），而低密度脂蛋白胆固醇或 TG 与 NHL 风险无关。调整降脂药物的使用并未显著改变结果。
这项前瞻性生物标志物研究为红细胞膜 SFA 水平升高对 NHL 风险有不良影响提供了支持性证据，但不能排除临床前影响。诊断前 TC 和 HDL-C 与 NHL 风险呈负相关，可能是由于反向因果关系或这些脂质和脂蛋白的保护作用所致。
