前瞻性分析红细胞膜多不饱和脂肪酸水平与非霍奇金淋巴瘤风险的关系。
A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma.
机构信息
Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
Leuk Lymphoma. 2022 Dec;63(14):3351-3361. doi: 10.1080/10428194.2022.2131419. Epub 2022 Oct 18.
Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses' Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03-1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23-4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.
已发表的研究报告表明，多不饱和脂肪酸（PUFA）的摄入与非霍奇金淋巴瘤（NHL）风险之间的关联并不一致。我们在护士健康研究和健康专业人员随访研究的参与者中进行了一项巢式病例对照研究，以评估红细胞（RBC）膜 PUFA 水平与 NHL 终点风险呈负相关的假设。我们通过队列/性别、年龄、种族和采血日期/时间，确认了 583 例 NHL 病例和 583 例匹配对照。我们使用逻辑回归估计 NHL 终点风险的比值比（OR）和 95%置信区间（CI）。RBC PUFA 水平与所有 NHL 风险均无关；20:2n-6 与滤泡性淋巴瘤风险相关（每增加一个标准差的比值比 [95%CI]：1.35 [1.03-1.77]），ω-6/ω-3 PUFA 比值与弥漫性大 B 细胞淋巴瘤风险相关（2.33 [1.23-4.43]）。总的来说，PUFA 在 NHL 病因学中没有表现出作用；这两个意外的阳性关联缺乏明确的生物学解释。
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