Radiation Oncology Department. Hospital Universitari Sant Joan de Reus, Institut d'Investigacions Sanitàries Pere Virgili, Universitat Rovira i Virgili, C/Sant Joan, 43200, Reus, Spain.
Strahlenther Onkol. 2012 Nov;188(11):975-81. doi: 10.1007/s00066-012-0170-8. Epub 2012 Aug 22.
Low-dose radiotherapy (LD-RT) has been used for several benign diseases, including arthrodegenerative and inflammatory pathologies. Despite its effectiveness in clinical practice, little is known about the mechanisms through which LD-RT modulates the various phases of the inflammatory response and about the optimal dose fractionation. The objective of this review is to deepen knowledge about the most effective LD-RT treatment schedule and radiobiological mechanisms underlying the anti-inflammatory effects of LD-RT in various in vitro experiments, in vivo studies, and clinical studies.
低剂量放射疗法（LD-RT）已被用于多种良性疾病，包括关节退行性和炎症性疾病。尽管在临床实践中它的效果显著，但对于 LD-RT 如何调节炎症反应的各个阶段以及最佳剂量分割的机制知之甚少。本文的目的是深入了解在各种体外实验、体内研究和临床研究中，LD-RT 治疗方案和放射生物学机制中最有效的 LD-RT 治疗方案，以及 LD-RT 在炎症反应中的抗炎作用。
