Wang Shu-Yuan, Wu Jia-Xing, An Xian, Yuan Zhen, Ren Yi-Fan, Yu Xiu-Feng, Tian Xiao-Dong, Wei Wei
School of Medicine, Nankai University, Tianjin 300071, China.
Senior Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
World J Radiol. 2025 Apr 28;17(4):101636. doi: 10.4329/wjr.v17.i4.101636.
Radiotherapy (RT) is a cornerstone of cancer treatment. Compared with conventional high-dose radiation, low-dose radiation (LDR) causes less damage to normal tissues while potentially modulating immune responses and inhibiting tumor growth. LDR stimulates both innate and adaptive immunity, enhancing the activity of natural killer cells, dendritic cells, and T cells. However, the mechanisms underlying the effects of LDR on the immune system remain unclear.
To explore the history, research hotspots, and emerging trends in immune response to LDR literature over the past two decades.
Publications on immune responses to LDR were retrieved from the Web of Science Core Collection. Bibliometric tools, including CiteSpace and HistCite, were used to identify historical features, active topics, and emerging trends in this field.
Analysis of 1244 publications over the past two decades revealed a significant surge in research on immune responses to LDR, particularly in the last decade. Key journals such as , , and published pivotal studies. Citation networks identified key studies by authors like Twyman-Saint Victor C (2015) and Vanpouille-Box C (2017). Keyword analysis revealed hotspots such as ipilimumab, stereotactic body RT, and targeted therapy, possibly identifying future research directions. Temporal variations in keyword clusters and alluvial flow maps illustrate the evolution of research themes over time.
This bibliometric analysis provides valuable insights into the evolution of studies on responses to LDR, highlights research trends, and identifies emerging areas for further investigation.
放射治疗（RT）是癌症治疗的基石。与传统高剂量辐射相比，低剂量辐射（LDR）对正常组织的损伤较小，同时可能调节免疫反应并抑制肿瘤生长。LDR可刺激先天免疫和适应性免疫，增强自然杀伤细胞、树突状细胞和T细胞的活性。然而，LDR对免疫系统影响的潜在机制仍不清楚。
探讨过去二十年中关于LDR文献免疫反应的研究历史、热点和新趋势。
从科学网核心合集检索关于LDR免疫反应的出版物。使用文献计量工具，包括CiteSpace和HistCite，来识别该领域的历史特征、活跃主题和新趋势。
对过去二十年1244篇出版物的分析显示，关于LDR免疫反应的研究显著增加，特别是在过去十年。诸如《 》《 》和《 》等关键期刊发表了关键研究。引文网络确定了Twyman-Saint Victor C（2015年）和Vanpouille-Box C（2017年）等作者的关键研究。关键词分析揭示了诸如伊匹单抗、立体定向体部放疗和靶向治疗等热点，可能确定了未来的研究方向。关键词聚类的时间变化和冲积流图说明了研究主题随时间的演变。
这项文献计量分析为LDR反应研究的演变提供了有价值的见解，突出了研究趋势，并确定了有待进一步研究的新领域。
