Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, 99 West Huai-hai Road, Xuzhou, Jiangsu 221002, China.
J Mol Neurosci. 2013 May;50(1):78-87. doi: 10.1007/s12031-012-9864-8. Epub 2012 Aug 3.
Glioblastoma is a kind of highly aggressive and incurable tumor with an average survival time of 12 months in our currently available treatment. The invasive cells are the sources of tumor recurrence and mechanisms of invasion are largely unknown. Identification of candidate genes important for invasion and migration is a hot spot of cancer biology. As one member of Bex protein family, Bex2 has its functions in the development of the nervous system and neurological diseases. Bex2 plays great roles in breast cancer, but its function and mechanisms in glioma progression remain unclear. In this study, we found Bex2 overexpression promoted cell migration and invasion, while Bex2 downregulation inhibited them. Meanwhile, we observed that Bex2 downregulation increased N-cadherin but decreased the excretion of MMP-2. Taken together, these data suggested that Bex2 promoted the progression of glioma by promoting cell migration and invasion, and these effects might be mediated by N-cadherin and MMP-2.
胶质母细胞瘤是一种高度侵袭性和不可治愈的肿瘤，在我们目前的治疗方法中，平均存活时间为 12 个月。侵袭性细胞是肿瘤复发的根源，侵袭机制在很大程度上尚不清楚。鉴定对侵袭和迁移重要的候选基因是癌症生物学的一个热点。Bex 蛋白家族的一员 Bex2 在神经系统的发育和神经退行性疾病中具有功能。Bex2 在乳腺癌中发挥着重要作用，但它在胶质瘤进展中的功能和机制尚不清楚。在这项研究中，我们发现 Bex2 过表达促进了细胞迁移和侵袭，而 Bex2 下调则抑制了它们。同时，我们观察到 Bex2 下调增加了 N-钙粘蛋白的表达，而降低了 MMP-2 的分泌。综上所述，这些数据表明 Bex2 通过促进细胞迁移和侵袭促进了胶质瘤的进展，而这些作用可能是由 N-钙粘蛋白和 MMP-2 介导的。
