Transcriptomic profiling of mice brain under Bex3 regulation.

BEX family genes are expressed in various tissues and play significant roles in neuronal development. A mouse model of gene knock-out was generated in this study, using the CRISPR-Cas9 system. Transcriptomic analysis of the brain was performed to identify genes and pathways under regulation. Essential biological functions under the control of related to brain development were identified. Ninety-five genes were differentially expressed under regulation, with 53 down and 42 up. Among down-regulated genes, is a member of zf-C2H2, is an X-linked lymphocyte regulated gene, is a hippocampal related gene, and are cortex related genes. Among the upregulated genes, is a zf protein, is a T cell-specific regulator, is a neuron-related gene, and is related to NF1. A total of 34 KEGG disease terms were identified under the regulation. The most prominent is non-syndromic X-linked mental retardation, where is enriched. Similarly, IRF, MBD, SAND, zf-BED, and zf-C2H2 were significantly enriched transcription factors. A further study is required to confirm and explain each aspect that has been identified in this study.