Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Blood Transfusion Organization, 146651157 Tehran, Iran.
Arch Virol. 2012 Dec;157(12):2441-5. doi: 10.1007/s00705-012-1443-3. Epub 2012 Aug 21.
HCV infection is known to be associated with clinical complications in thalassemic patients. D and H genotypes of SEN virus (SENV) are associated with blood-product transfusion and possibly non-A-to-E hepatitis. In this study, SENV viremia and its effect on liver ALT level in thalassemic patients, thalassemic patients infected with HCV, and HCV-infected patients were examined. Semi-nested PCR was conducted for detection of genotype H and D DNA, and the level of alanine aminotransferase (ALT) was measured. There was no significant difference in the mean ALT level in the studied groups and between SENV-positive and SENV-negative individuals. The results also showed that SENV infection does not affect the ALT level in these patients.
HCV 感染已知与地中海贫血患者的临床并发症有关。SEN 病毒（SENV）的 D 和 H 基因型与血液制品输注有关，可能与非 A 至 E 型肝炎有关。在这项研究中，检测了 SENV 血症及其对地中海贫血患者、HCV 感染的地中海贫血患者和 HCV 感染患者的肝 ALT 水平的影响。采用半巢式 PCR 检测基因型 H 和 D 的 DNA，测量丙氨酸氨基转移酶（ALT）的水平。研究组的平均 ALT 水平以及 SENV 阳性和 SENV 阴性个体之间无显著差异。结果还表明，SENV 感染不会影响这些患者的 ALT 水平。
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