Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan National University, Busan, Korea.
Head Neck. 2013 Sep;35(9):1319-22. doi: 10.1002/hed.23129. Epub 2012 Aug 21.
Nodal metastasis in papillary thyroid cancer (PTC) usually occurs in the central compartment of the ipsilateral neck and spreads laterally. The purpose of this study was to evaluate the diagnostic accuracy of frozen biopsy for quantitative nodal evaluation of central neck metastasis in PTC.
In all, 252 patients with PTC underwent total thyroidectomy with bilateral central neck dissection (CND). All tissues from ipsilateral CND were examined by frozen biopsy.
Among them, 53% of patients had central neck metastasis. The sensitivity and specificity of frozen biopsy for central neck metastasis were 92% and 99%, respectively. The positive predictive value and the negative predictive value were 99% and 84%, respectively. The diagnostic accuracy for the exact number of metastatic nodes was 91% compared to permanent biopsy.
Frozen biopsy for quantitative analysis of central compartment is a useful tool for the precise evaluation of central lymphatic status intraoperatively with a high sensitivity and specificity.
甲状腺乳头状癌（PTC）的淋巴结转移通常发生在同侧颈部中央区，并向外侧扩散。本研究旨在评估冰冻活检对 PTC 中央颈部转移淋巴结定量评估的诊断准确性。
共 252 例 PTC 患者行甲状腺全切除术及双侧中央颈部清扫术（CND）。同侧 CND 的所有组织均行冰冻活检检查。
其中 53%的患者存在中央颈部转移。冰冻活检对中央颈部转移的灵敏度和特异性分别为 92%和 99%，阳性预测值和阴性预测值分别为 99%和 84%。与常规石蜡活检相比，冰冻活检对转移淋巴结确切数量的诊断准确率为 91%。
冰冻活检对中央区进行定量分析是一种有用的工具，可在术中精确评估中央淋巴结状态，具有较高的灵敏度和特异性。
