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结核性脑膜炎:疑似病例即进行治疗。

Tuberculous meningitis: treat upon suspicion.

作者信息

Sonneveld Myrthe Elisabeth, Zinkstok S M, Nellen F J B, Holleboom Adriaan G

机构信息

Department of Internal Medicine, University of Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands.

出版信息

BMJ Case Rep. 2012 Aug 18;2012:bcr2012006627. doi: 10.1136/bcr-2012-006627.

DOI:10.1136/bcr-2012-006627
PMID:22907858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4543708/
Abstract

A 58-year-old man from Surinam was referred because of nausea, vomiting, weight loss, ascites and an altered mental state. Tuberculous meningitis was suspected upon examination of the cerebrospinal fluid and antituberculous treatment was initiated. However, the patient did not recover but developed haemiplegia with recurrent aspiration pneumonias. This case illustrates that empiric antituberculous treatment is warranted upon clinical suspicion, since no fast, sensitive diagnostic tests are available to date.

摘要

一名来自苏里南的58岁男子因恶心、呕吐、体重减轻、腹水和精神状态改变而前来就诊。脑脊液检查怀疑为结核性脑膜炎,并开始进行抗结核治疗。然而,患者并未康复,反而出现偏瘫并反复发生吸入性肺炎。该病例表明,由于目前尚无快速、灵敏的诊断测试,因此在临床怀疑时进行经验性抗结核治疗是必要的。

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Using likelihood ratios to estimate diagnostic accuracy of a novel multiplex nested PCR in extra-pulmonary tuberculosis.利用似然比估计新型多重巢式 PCR 在肺外结核诊断中的准确性。
Int J Tuberc Lung Dis. 2012 Feb;16(2):240-7. doi: 10.5588/ijtld.11.0322.
2
Tuberculosis versus lymphoma in the abdominal lymph nodes: a comparative study using contrast-enhanced MRI.腹腔淋巴结结核与淋巴瘤的对比研究:应用增强 MRI 的研究。
Eur J Radiol. 2012 Oct;81(10):2513-7. doi: 10.1016/j.ejrad.2011.11.004. Epub 2011 Dec 9.
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Sensitivity and specificity of immunocytochemical staining of mycobacterial antigens in the cytoplasm of cerebrospinal fluid macrophages for diagnosing tuberculous meningitis.免疫细胞化学染色检测脑脊液巨噬细胞细胞质中分枝杆菌抗原对诊断结核性脑膜炎的敏感性和特异性。
J Clin Microbiol. 2011 Sep;49(9):3388-91. doi: 10.1128/JCM.01323-11. Epub 2011 Jul 27.
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Central nervous system tuberculosis.中枢神经系统结核
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Multiplex PCR for rapid diagnosis of tuberculous meningitis.多重 PCR 快速诊断结核性脑膜炎。
J Neurol. 2011 Oct;258(10):1781-7. doi: 10.1007/s00415-011-6010-4. Epub 2011 Mar 31.
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Tuberculous meningitis in Denmark: a review of 50 cases.丹麦结核性脑膜炎:50 例病例回顾。
BMC Infect Dis. 2011 Feb 22;11:47. doi: 10.1186/1471-2334-11-47.
7
Diagnostic value of adenosine deaminase in cerebrospinal fluid for tuberculous meningitis: a meta-analysis.腺苷脱氨酶在脑脊液中对结核性脑膜炎的诊断价值:一项荟萃分析。
Int J Tuberc Lung Dis. 2010 Nov;14(11):1382-7.
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Tuberculous meningitis.结核性脑膜炎。
Acta Neurol Scand. 2010 Aug;122(2):75-90. doi: 10.1111/j.1600-0404.2009.01316.x. Epub 2010 Jan 6.
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Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis.地塞米松、脑脊液基质金属蛋白酶浓度与结核性脑膜炎的临床转归。
PLoS One. 2009 Sep 30;4(9):e7277. doi: 10.1371/journal.pone.0007277.
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[Three patients with tuberculous meningitis: treatment started at tentative diagnosis].3例结核性脑膜炎患者:初步诊断时即开始治疗
Ned Tijdschr Geneeskd. 2008 Mar 15;152(11):593-8.