Daelman L, Maitrot A, Maarouf A, Chaunu M P, Papeix C, Tourbah A
Department of Neurology, CHU de Reims, Reims, France.
Mult Scler. 2012 Nov;18(11):1647-9. doi: 10.1177/1352458512458009. Epub 2012 Aug 20.
We report the case of a woman with multiple sclerosis who developed a severe neurological condition following natalizumab (NZB) withdrawal and soon after fingolimod (FTY) initiation. FTY was started 3.5 months after a two-year NZB treatment. Fifteen days later, she suffered partial repetitive seizures followed by a tonicoclonic seizure. This was associated with attention difficulties and an increased asthenia. Brain MRI follow-up disclosed large demyelinating active lesions in favour of disease reactivation. This case suggests that FTY introduction may occur less than three months after NZB withdrawal.
我们报告了一例多发性硬化症女性患者的病例，该患者在停用那他珠单抗（NZB）并开始使用芬戈莫德（FTY）后不久出现了严重的神经状况。在接受了两年的NZB治疗后3.5个月开始使用FTY。15天后，她出现了部分重复性癫痫发作，随后是强直阵挛性发作。这与注意力障碍和乏力加重有关。脑部MRI随访显示有大量脱髓鞘活动性病变，提示疾病重新激活。该病例表明，在停用NZB后不到三个月可能就开始使用FTY。
