Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
IEEE Trans Biomed Eng. 2012 Nov;59(11):3028-38. doi: 10.1109/TBME.2012.2213340. Epub 2012 Aug 15.
A computational platform has been developed to perform simulation, visualization, and postprocessing analysis of the aggregation process of magnetic particles within a fluid environment such as small arteries and arterioles or fluid-filled cavities of the human body. The mathematical models needed to describe the physics of the system are presented in detail and also computational algorithms needed for efficient computation of these models are described. A number of simulation results demonstrate the simulation capabilities of the platform and preliminary experimental results validate simulation predictions. The platform can be used to design optimal strategies for magnetic steering and magnetic targeting of drug-loaded magnetic microparticles.
已经开发了一个计算平台，用于模拟、可视化和后处理分析磁粒子在流体环境（如小动脉和小动脉或人体充满液体的腔隙）中的聚集过程。详细介绍了描述系统物理特性所需的数学模型，并描述了用于有效计算这些模型的计算算法。许多模拟结果展示了该平台的模拟能力，初步实验结果验证了模拟预测。该平台可用于设计载药磁微球的磁导向和磁靶向的最佳策略。
