人巨细胞病毒抑制剂 AL18 也对甲型和乙型流感病毒具有活性。
Human cytomegalovirus inhibitor AL18 also possesses activity against influenza A and B viruses.
机构信息
Department of Molecular Medicine, University of Padua, Padua, Italy.
出版信息
Antimicrob Agents Chemother. 2012 Nov;56(11):6009-13. doi: 10.1128/AAC.01219-12. Epub 2012 Aug 20.
Abstract
AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.
摘要
AL18 是一种人巨细胞病毒 DNA 聚合酶抑制剂，意外地发现它还可以阻断甲型流感病毒 PB1 和 PA 聚合酶亚基之间的相互作用。此外，AL18 能有效抑制甲型流感病毒聚合酶活性以及甲型和乙型流感病毒的整体复制。提出了一个分子模型来解释 AL18 与巨细胞病毒和流感靶标的结合。因此，AL18 为开发新型抗病毒药物提供了一个有趣的先导化合物。
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