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三叶鬼针草花精油的化学成分及体外抗菌活性

Chemical composition and in vitro antimicrobial activity of the essential oil of the flowers of Tridax procumbens.

作者信息

Joshi Rajesh K, Badakar Vijaylaxmi

机构信息

Department of Phytochemistry, Regional Medical Research Centre (Indian Council of Medical Research), Nehru Nagar, Belgaum, Karnataka-590 010 India.

出版信息

Nat Prod Commun. 2012 Jul;7(7):941-2.

Abstract

The essential oil of the flowers of Tridax procumbens L. was obtained by hydro-distillation and analyzed by gas chromatography equipped with a flame ionization detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC/MS). Twenty-six compounds were identified, which comprised 90.6% of the total constituents. The most abundant compound was (Z)-falcarinol (25.9%), followed by alpha-selinene (15.3%), limonene (8.3%) and zerumbone (4.3%). Antimicrobial activity was tested against six Gram-positive and eight Gram-negative bacteria, and three fungi. The oil was active against the tested Gram-positive bacteria at a concentration range of 0.14 +/- 0.03 - 0.57 +/- 0.05 mg/mL, while 0.67 +/- 0.12 - 4.58 +/- 0.41 mg/mL was effective against the studied Gram-negative bacteria. Remarkable antifungal activity was found against the tested fungi at a concentration range of 0.06 +/- 0.008 - 0.10 +/- 0.01 mg/mL.

摘要

通过水蒸馏法获得了三叶鬼针草花的精油,并采用配备火焰离子化检测器的气相色谱仪(GC-FID)和气相色谱-质谱联用仪(GC/MS)对其进行了分析。共鉴定出26种化合物,占总成分的90.6%。含量最高的化合物是(Z)-法卡林二醇(25.9%),其次是α-芹子烯(15.3%)、柠檬烯(8.3%)和姜味草酮(4.3%)。对6种革兰氏阳性菌、8种革兰氏阴性菌和3种真菌进行了抗菌活性测试。该精油在0.14±0.03 - 0.57±0.05 mg/mL的浓度范围内对测试的革兰氏阳性菌有活性,而在0.67±0.12 - 4.58±0.41 mg/mL的浓度范围内对所研究的革兰氏阴性菌有效。在0.06±0.008 - 0.10±0.01 mg/mL的浓度范围内,发现该精油对测试的真菌具有显著的抗真菌活性。

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