Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
J Dig Dis. 2012 Sep;13(9):466-71. doi: 10.1111/j.1751-2980.2012.00621.x.
The aim was to determine the detection rates and characteristics of large or proximal serrated polyps in Chinese patients undergoing screening colonoscopy.
Consecutive screening colonoscopies performed between 2008 and 2011 were analyzed. Serrated polyps consisted of all hyperplastic polyps, sessile serrated adenomas and traditional serrated adenomas. Large serrated polyps were defined as serrated polyps with a diameter ≥ 10 mm. Lesions proximal to the descending colon were considered as proximal lesions. Advanced neoplasia included invasive adenocarcinomas, adenomas with high grade dysplasia, adenomas with any villous histology and tubular adenomas ≥ 10 mm.
In total, 1282 colonoscopies were included. The detection rates for adenoma, advanced neoplasia, proximal serrated polyps and large serrated polyps were 26.1%, 10.5%, 7.2% and 2.3%, respectively. There was a significant association between synchronous advanced neoplasia and large serrated polyps (P = 0.002) or proximal serrated polyps (P = 0.013). Age ≥ 55 years (OR 1.9, 95% CI 1.2-2.8) and the presence of advanced neoplasia (OR 1.8, 95% CI 1.0-3.1) were significantly associated with the presence of large or proximal serrated polyps. Males had more advanced neoplasia (OR 2.0, 95% CI 1.4-2.9), but not more large or proximal serrated polyps, than females.
Large and proximal serrated polyps were detected in 2.3% and 7.2% of Chinese patients undergoing screening colonoscopies, respectively. Individuals with large or proximal serrated polyps have a higher risk of synchronous advanced neoplasia.
旨在确定在接受筛查性结肠镜检查的中国患者中，大型或近端锯齿状息肉的检出率和特征。
分析了 2008 年至 2011 年间连续进行的筛查性结肠镜检查。锯齿状息肉包括所有增生性息肉、无蒂锯齿状腺瘤和传统锯齿状腺瘤。大型锯齿状息肉定义为直径≥10mm 的锯齿状息肉。降结肠近端的病变被认为是近端病变。高级别瘤变包括浸润性腺癌、高级别异型增生腺瘤、任何绒毛状组织学的腺瘤和≥10mm 的管状腺瘤。
共纳入 1282 例结肠镜检查。腺瘤、高级别瘤变、近端锯齿状息肉和大型锯齿状息肉的检出率分别为 26.1%、10.5%、7.2%和 2.3%。同步高级别瘤变与大型锯齿状息肉（P=0.002）或近端锯齿状息肉（P=0.013）之间存在显著相关性。年龄≥55 岁（OR 1.9，95%CI 1.2-2.8）和存在高级别瘤变（OR 1.8，95%CI 1.0-3.1）与大型或近端锯齿状息肉的存在显著相关。与女性相比，男性的高级别瘤变更多（OR 2.0，95%CI 1.4-2.9），但大型或近端锯齿状息肉并不更多。
在中国接受筛查性结肠镜检查的患者中，分别有 2.3%和 7.2%检出大型和近端锯齿状息肉。有大型或近端锯齿状息肉的患者有更高的同步高级别瘤变风险。
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