Roy-Chaudhury Prabir, El-Khatib Mahmoud, Campos-Naciff Begona, Wadehra Davinder, Ramani Karthik, Leesar Massoud, Mistry Meenakshi, Wang Yang, Chan Jenq-Shyong, Lee Timmy, Munda Rino
Cincinnati VA Medical Center, Cincinnati, Ohio, USA.
Semin Dial. 2012 Sep-Oct;25(5):495-504. doi: 10.1111/j.1525-139X.2012.01091.x. Epub 2012 Aug 22.
Although the arteriovenous fistula (AVF) is the preferred mode of dialysis vascular access, AVF maturation failure remains a huge clinical problem, often resulting in a prolonged duration of use of tunneled dialysis catheters. In contrast, polytetrafluoroethylene (PTFE) grafts do not suffer from early failure, but have significant problems with later stenosis and thrombosis. This review will initially summarize the pathology and pathogenesis of PTFE graft dysfunction and will then use this as a basis for describing some novel therapies, which may have the potential to reduce PTFE graft dysfunction. Finally, we will emphasize that the introduction of such therapies could be an important first step toward individualizing overall vascular access care.
尽管动静脉内瘘（AVF）是透析血管通路的首选方式，但AVF成熟失败仍是一个巨大的临床问题，常导致隧道式透析导管使用时间延长。相比之下，聚四氟乙烯（PTFE）移植物不存在早期失败问题，但后期存在明显的狭窄和血栓形成问题。本综述将首先总结PTFE移植物功能障碍的病理和发病机制，然后以此为基础描述一些可能有潜力减少PTFE移植物功能障碍的新疗法。最后，我们将强调引入此类疗法可能是实现整体血管通路个体化护理的重要第一步。
