戊糖素的全合成。
Total synthesis of pentosidine.
机构信息
Department of Chemistry, 1-014 Center for Science and Technology, Syracuse University, Syracuse, New York 13244, USA.
出版信息
Org Lett. 2012 Sep 7;14(17):4678-81. doi: 10.1021/ol3021226. Epub 2012 Aug 21.
PMID:22909052
Abstract
Pentosidine, a biologically important advanced glycation endproduct, has been accessed in a rapid, high-yielding manner. The synthesis was accomplished via a six-step sequence starting with 3-amino-2-chloropyridine and features a palladium-catalyzed tandem cross-coupling/cyclization to construct the imidazo[4,5-b]pyridine core.
摘要
戊烯二醛，一种重要的生物糖基化终产物，已经被快速、高产的方式获取。该合成通过六步序列从 3-氨基-2-氯吡啶开始，采用钯催化的串联交叉偶联/环化来构建咪唑[4,5-b]吡啶核心。
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