Laboratório de Pesquisa em Virologia Animal, Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Transbound Emerg Dis. 2013 Dec;60(6):552-5. doi: 10.1111/j.1865-1682.2012.01372.x. Epub 2012 Aug 22.
Bovine vaccinia (BV), a zoonosis caused by Vaccinia virus (VACV), affects dairy cattle and milkers, causing economic, veterinary and human health impacts. Despite such impacts, there are no experimental studies about the pathogenesis of BV in cows to assess whether there is a systemic spread of the virus and whether there are different ways of VACV shedding. Trying to answer some of these questions, a study was proposed using experimental inoculation of VACV in cows. All experimentally infected cows developed lesions compatible with VACV infection in cattle. Two of the six animals presented VACV DNA in blood and faecal samples, starting at the 2nd and the 3rd day post-infection (d.p.i.), respectively, and lasting until the 36th d.p.i., in an intermittent way. This study provides new evidence that VACV can be detected in blood and faeces of infected cows, suggesting that BV could be a systemic disease, and also bringing new information about the epidemiology and pathogenesis of BV.
牛痘（BV）是由牛痘病毒（VACV）引起的一种人畜共患病，影响奶牛和挤奶工，造成经济、兽医和人类健康方面的影响。尽管有这些影响，但目前还没有关于牛 BV 发病机制的实验研究，以评估病毒是否有全身性传播，以及是否有不同的 VACV 脱落方式。为了回答其中的一些问题，提出了一项使用 VACV 对奶牛进行实验接种的研究。所有实验感染的奶牛都出现了与牛痘病毒感染相符的病变。在感染后的第 2 天和第 3 天，有 2 只动物的血液和粪便样本中分别出现了 VACV DNA，并一直持续到第 36 天，呈间歇性出现。这项研究提供了新的证据，表明感染牛的血液和粪便中可以检测到 VACV，这表明 BV 可能是一种全身性疾病，也为 BV 的流行病学和发病机制提供了新的信息。
