Department of Neurology, The Affiliated Hospital of the Medical College of Qingdao University, 59 Haier Road, Qingdao, Shandong Province 266100, PR China.
BMC Neurol. 2012 Aug 22;12:79. doi: 10.1186/1471-2377-12-79.
Vertebral artery dissection (VAD) is often associated with trauma or occurs spontaneously, inevitably causing some neurological deficits. Even though acute infection can be related to the development of spontaneous VAD (sVAD), VAD associated with viral meningitis has never been reported in the literature.
A 42-year-old man with fever, sore throat, and runny nose developed sudden onset of occipital headache, vertigo, transient confusion, diplopia, and ataxia. Brain stem encephalitis was diagnosed initially because the cerebrospinal fluid (CSF) study showed inflammatory changes. However, subsequent diffusion-weighted (DWI) magnetic resonance imaging of his brain demonstrated left lateral medullary infarction, and the digital subtraction angiography (DSA) confirmed VAD involving left V4 segment of the artery. Consequently, the patient was diagnosed as VAD accompanied by viral meningitis.
This case suggests that viral meningitis might lead to inflammatory injury of the vertebral arterial wall, even sVAD with multiple neurological symptoms.
椎动脉夹层(VAD)常与创伤有关,或自发发生,不可避免地导致一些神经功能缺损。尽管急性感染可能与自发性 VAD(sVAD)的发展有关,但文献中从未报道过与病毒性脑膜炎相关的 VAD。
一名 42 岁男性,发热、咽痛、流涕,突发枕部头痛、眩晕、一过性意识混乱、复视和共济失调。最初诊断为脑干脑炎,因为脑脊液(CSF)研究显示炎症改变。然而,随后的脑弥散加权(DWI)磁共振成像显示左侧延髓梗死,数字减影血管造影(DSA)证实 VAD 累及动脉左 V4 段。因此,患者被诊断为伴有病毒性脑膜炎的 VAD。
本病例提示病毒性脑膜炎可能导致椎动脉壁的炎症损伤,甚至导致 sVAD 伴多种神经症状。