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Moving away from candidate genes: a 'genome-wise' discovery of gemcitabine myelotoxicity.

作者信息

Innocenti Federico

机构信息

University of North Carolina at Chapel Hill, Institute for Pharmacogenomics & Individualized Therapy, Eshelman School of Pharmacy, School of Medicine, Chapel Hill, NC 27599-7361, USA.

出版信息

Pharmacogenomics. 2012 Jul;13(10):1113-4. doi: 10.2217/pgs.12.96.

DOI:10.2217/pgs.12.96
PMID:22909200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4131678/
Abstract
摘要

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Systemic therapies for pancreatic cancer--the role of pharmacogenetics.胰腺癌的系统治疗——药物遗传学的作用。
Curr Drug Targets. 2012 Jun;13(6):811-28. doi: 10.2174/138945012800564068.
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The limits of genome-wide methods for pharmacogenomic testing.全基因组方法在药物基因组学检测中的局限性。
Pharmacogenet Genomics. 2012 Apr;22(4):261-72. doi: 10.1097/FPC.0b013e328350ca5f.
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A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.一项全基因组关联研究确定了接受吉西他滨治疗的癌症患者血液学毒性的四个遗传标记物。
Pharmacogenet Genomics. 2012 Apr;22(4):229-35. doi: 10.1097/FPC.0b013e32834e9eba.
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A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.一项针对接受吉西他滨治疗的胰腺癌患者总体生存的全基因组关联研究，该研究来自 CALGB 80303 试验。
Clin Cancer Res. 2012 Jan 15;18(2):577-84. doi: 10.1158/1078-0432.CCR-11-1387. Epub 2011 Dec 5.
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Nat Rev Clin Oncol. 2011 Feb 8;8(7):439-44. doi: 10.1038/nrclinonc.2011.1.
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