血小板依赖性血栓描记术显示体外心肺旁路手术后凝血酶生成的明显模式：潜在影响。
Platelet-dependent thrombography gives a distinct pattern of in vitro thrombin generation after surgery with cardio-pulmonary bypass: potential implications.
机构信息
Laboratoire d'Hématologie et Institut Cardiovasculaire Nancy, Centre Hospitalier Universitaire, Nancy, France.
Inserm U961, Nancy Université, Nancy, France.
出版信息
Thromb J. 2012 Aug 21;10(1):15. doi: 10.1186/1477-9560-10-15.
BACKGROUND
Bleeding remains a potentially lethal complication of cardio-pulmonary bypass (CPB) surgery. The purpose of this study was to obtain a better insight into in vitro thrombin generation in the context of CPB.
METHODS
We used Calibrated Automated Thrombography to assess blood coagulation of 10 low-risk patients operated for valve replacement with CPB, under 2 experimental conditions, one implicating platelets as platelet dysfunction has been described to occur during CPB.
RESULTS
Our main finding was that CPB-induced coagulopathy was differently appreciated depending on the presence or absence of platelets: the decrease in thrombin generation was much less pronounced in their presence (mean endogenous thrombin potential change values before and after CPB were -3.9% in the presence of platelets and -39.6% in their absence).
CONCLUSION
Our results show that experimental conditions have a profound effect in the study of in vitro thrombin generation in the context of CPB.
背景
出血仍然是体外心肺循环（CPB）手术潜在的致命并发症。本研究的目的是更好地了解 CPB 背景下体外凝血酶生成的情况。
方法
我们使用校准自动血栓形成法评估了 10 名低危瓣膜置换术患者 CPB 下的血液凝固情况，在两种实验条件下，一种是血小板功能障碍，因为已有研究描述了 CPB 期间会发生血小板功能障碍。
结果
我们的主要发现是，CPB 引起的凝血功能障碍的评估因血小板的存在与否而不同：在血小板存在的情况下，凝血酶生成的减少不那么明显（CPB 前后内源性凝血酶潜能变化值在血小板存在时为-3.9%，在血小板不存在时为-39.6%）。
结论
我们的结果表明，实验条件对 CPB 背景下体外凝血酶生成的研究有深远的影响。
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