Kühn Tilman, Kroke Anja, Remer Thomas, Schönau Eckhard, Buyken Anette E
Department of Nutritional, Food and Consumer Sciences, University of Applied Sciences Fulda, Fulda, Germany; Department of Cancer Epidemiology, German Cancer Research Center - DKFZ, Heidelberg, Germany.
Matern Child Nutr. 2014 Oct;10(4):642-9. doi: 10.1111/j.1740-8709.2012.00443.x. Epub 2012 Aug 22.
Nutritive and bioactive components of human milk could be involved in programming metabolic systems that affect bone growth throughout the life course. Bone properties in childhood and adolescence might differ, depending on breastfeeding duration. Thus, breastfeeding could be a relevant factor in the context of primary osteoporosis prevention. The prospective association between breastfeeding duration and bone properties was investigated using the data of 284 participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed Study. Breastfeeding duration was assessed during infancy. Bone properties were measured by peripheral quantitative computed tomography (pQCT) at ages 5-23 years. Cortical volumetric bone mineral density, cortical bone mineral content, strength strain index, total cross-sectional area of the bone and cross-sectional area of the cortical bone were determined at the 65% site of the radius. Linear regression analyses were performed to check for differences in pQCT parameters of subjects who had not or shortly been breastfed (0-16 weeks) and subjects who had been breastfed for a long duration (≥17 weeks). Multivariable models adjusted for age, gender, forearm length, muscle cross-sectional area, body mass index standard deviation score (SDS), height SDS and socio-economic status did not yield associations between breastfeeding duration and pQCT parameters. These findings suggest neither protective nor adverse effects of prolonged breastfeeding on bone health in childhood and adolescence. Influences of early nutrition on bone growth might be overridden by current effects of mechanical loads on bone physiology.
人乳中的营养和生物活性成分可能参与了对代谢系统的编程，这些代谢系统会影响整个生命过程中的骨骼生长。儿童期和青春期的骨骼特性可能会有所不同，这取决于母乳喂养的持续时间。因此，母乳喂养可能是原发性骨质疏松症预防背景下的一个相关因素。利用多特蒙德营养与人体测量纵向设计研究中284名参与者的数据，研究了母乳喂养持续时间与骨骼特性之间的前瞻性关联。在婴儿期评估母乳喂养持续时间。在5至23岁时通过外周定量计算机断层扫描（pQCT）测量骨骼特性。在桡骨65%处测定皮质骨体积骨密度、皮质骨矿物质含量、强度应变指数、骨总横截面积和皮质骨横截面积。进行线性回归分析，以检查未母乳喂养或短期母乳喂养（0至16周）的受试者与长期母乳喂养（≥17周）的受试者在pQCT参数上的差异。针对年龄、性别、前臂长度、肌肉横截面积、体重指数标准差评分（SDS）、身高SDS和社会经济地位进行调整的多变量模型未显示母乳喂养持续时间与pQCT参数之间存在关联。这些发现表明，延长母乳喂养对儿童期和青春期骨骼健康既没有保护作用也没有不良影响。早期营养对骨骼生长的影响可能会被当前机械负荷对骨骼生理的影响所掩盖。
