Institute of Medical Engineering, University of Lübeck, Lübeck, Germany.
Z Med Phys. 2012 Dec;22(4):323-34. doi: 10.1016/j.zemedi.2012.07.004. Epub 2012 Aug 19.
Magnetic Particle Imaging (MPI) is a recently invented tomographic imaging method that quantitatively measures the spatial distribution of a tracer based on magnetic nanoparticles. The new modality promises a high sensitivity and high spatial as well as temporal resolution. There is a high potential of MPI to improve interventional and image-guided surgical procedures because, today, established medical imaging modalities typically excel in only one or two of these important imaging properties. MPI makes use of the non-linear magnetization characteristics of the magnetic nanoparticles. For this purpose, two magnetic fields are created and superimposed, a static selection field and an oscillatory drive field. If superparamagnetic iron-oxide nanoparticles (SPIOs) are subjected to the oscillatory magnetic field, the particles will react with a non-linear magnetization response, which can be measured with an appropriate pick-up coil arrangement. Due to the non-linearity of the particle magnetization, the received signal consists of the fundamental excitation frequency as well as of harmonics. After separation of the fundamental signal, the nanoparticle concentration can be reconstructed quantitatively based on the harmonics. The spatial coding is realized with the static selection field that produces a field-free point, which is moved through the field of view by the drive fields. This article focuses on the frequency-based image reconstruction approach and the corresponding imaging devices while alternative concepts like x-space MPI and field-free line imaging are described as well. The status quo in hardware realization is summarized in an overview of MPI scanners.
磁共振粒子成像(MPI)是一种新发明的层析成像方法,它基于磁性纳米粒子定量测量示踪剂的空间分布。这种新的模态有望具有高灵敏度和高空间及时间分辨率。MPI 有很大的潜力来改善介入性和图像引导的手术程序,因为目前,既定的医学成像方式通常只擅长于这些重要成像特性中的一两个。MPI 利用了磁性纳米粒子的非线性磁化特性。为此,创建并叠加了两个磁场,一个是静态选择场,另一个是振荡驱动场。如果超顺磁性氧化铁纳米粒子(SPIOs)受到振荡磁场的作用,粒子将产生非线性的磁化响应,这可以通过适当的拾波线圈排列来测量。由于粒子磁化的非线性,接收信号由基本激发频率和高次谐波组成。在分离出基本信号后,可以根据谐波定量重建纳米粒子的浓度。通过静态选择场实现空间编码,该选择场产生一个无磁场点,通过驱动场在视场中移动。本文主要关注基于频率的图像重建方法和相应的成像设备,同时也描述了其他概念,如 x 空间 MPI 和无磁场线成像。MPI 扫描仪的硬件实现现状在概述中进行了总结。
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