Philips Technologie GmbH Innovative Technologies, Research Laboratories, Röntgenstraße 24-26, Hamburg, Germany.
J Cardiovasc Comput Tomogr. 2012 May-Jun;6(3):149-53. doi: 10.1016/j.jcct.2012.04.007. Epub 2012 Apr 26.
Magnetic particle imaging (MPI) is a new medical imaging technique which performs a direct measurement of magnetic nanoparticles, also known as superparamagnetic iron oxide. MPI can acquire quantitative images of the local distribution of the magnetic material with high spatial and temporal resolution. Its sensitivity is well above that of other methods used for the detection and quantification of magnetic materials, for example, magnetic resonance imaging. On the basis of an intravenous injection of magnetic particles, MPI has the potential to play an important role in medical application areas such as cardiovascular, oncology, and also in exploratory fields such as cell labeling and tracking. Here, we present an introduction to the basic function principle of MPI, together with an estimation of the spatial resolution and the detection limit. Furthermore, the above-mentioned medical applications are discussed with respect to an applicability of MPI.
磁共振粒子成像（MPI）是一种新的医学成像技术，可直接测量超顺磁氧化铁等磁性纳米粒子。MPI 可以以高时空分辨率获取磁性材料局部分布的定量图像。其灵敏度明显高于其他用于检测和量化磁性材料的方法，例如磁共振成像。基于静脉内注射磁性粒子，MPI 有可能在心血管、肿瘤等医学应用领域以及细胞标记和跟踪等探索性领域发挥重要作用。本文介绍了 MPI 的基本功能原理，并对空间分辨率和检测极限进行了估计。此外，还讨论了上述医学应用领域中 MPI 的适用性。
