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Cholinergic-rich transplants alleviate cognitive deficits in lesioned rats, but exacerbate response to cholinergic drugs.

作者信息

Hodges H, Allen Y, Sinden J, Lantos P L, Gray J A

机构信息

Department of Psychology (MRC Brain, Behaviour and Psychiatry Research Group), Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, England, UK.

出版信息

Prog Brain Res. 1990;82:347-58. doi: 10.1016/s0079-6123(08)62622-9.

DOI:10.1016/s0079-6123(08)62622-9
PMID:2290948
Abstract
摘要

相似文献

1
Cholinergic-rich transplants alleviate cognitive deficits in lesioned rats, but exacerbate response to cholinergic drugs.富含胆碱能的移植体可缓解受损大鼠的认知缺陷，但会加剧对胆碱能药物的反应。
Prog Brain Res. 1990;82:347-58. doi: 10.1016/s0079-6123(08)62622-9.
2
Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system--II. Cholinergic drugs as probes to investigate lesion-induced deficits and transplant-induced functional recovery.富含胆碱能的神经移植物对前脑胆碱能投射系统兴奋性毒性损伤后大鼠放射状迷宫行为表现的影响——II. 作为研究损伤诱导缺陷和移植诱导功能恢复探针乙酰胆碱能药物。
Neuroscience. 1991;45(3):609-23. doi: 10.1016/0306-4522(91)90274-r.
3
Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system--I. Amelioration of cognitive deficits by transplants into cortex and hippocampus but not into basal forebrain.富含胆碱能的神经移植对前脑胆碱能投射系统兴奋性毒性损伤后大鼠放射状迷宫行为的影响——I. 移植到皮层和海马而非基底前脑可改善认知缺陷。
Neuroscience. 1991;45(3):587-607. doi: 10.1016/0306-4522(91)90273-q.
4
Spatial memory deficit resulting from ischemia-induced damage to the hippocampus is ameliorated by intra-hippocampal transplants of fetal hippocampal neurons.海马体缺血性损伤导致的空间记忆缺陷可通过海马内移植胎儿海马神经元得到改善。
Prog Brain Res. 1990;82:359-66. doi: 10.1016/s0079-6123(08)62623-0.
5
The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats.胆碱能药物和富含胆碱能的胎儿神经移植对大鼠酒精诱导的放射状迷宫行为缺陷的影响。
Behav Brain Res. 1991 Apr 18;43(1):7-28. doi: 10.1016/s0166-4328(05)80048-8.
6
Significance of the character and probability of reinforcement in animals with transplantation of various embryonal tissue structures.不同胚胎组织结构移植动物中强化的特征及可能性的意义
Neurosci Behav Physiol. 1991 Nov-Dec;21(6):523-5. doi: 10.1007/BF01185943.
7
Transplantation of fetal hippocampus may prevent or produce behavioral recovery from hippocampal ablation and recovery persists after removal of the transplant.移植胎儿海马体可能预防或促使海马体切除后的行为恢复，并且在移除移植物后恢复仍会持续。
Prog Brain Res. 1990;82:367-76. doi: 10.1016/s0079-6123(08)62624-2.
8
Participation of graft and host brain dendrites in the establishment of interconnections.移植物和宿主脑树突在建立相互连接中的参与。
Prog Brain Res. 1990;82:277-86. doi: 10.1016/s0079-6123(08)62614-x.
9
Analysis of neocortical grafts placed into focal ischemic lesions in adult rats.成年大鼠局灶性缺血性损伤中植入的新皮质移植物分析。
Neurosci Lett. 1995 Dec 1;201(1):69-72. doi: 10.1016/0304-3940(95)12140-y.
10
Morris water maze analysis of 192-IgG-saporin-lesioned rats and porcine cholinergic transplants to the hippocampus.对192-IgG-皂草素损伤大鼠和海马体猪胆碱能移植体进行莫里斯水迷宫分析。
Cell Transplant. 1999 Jan-Feb;8(1):131-42. doi: 10.1177/096368979900800105.

引用本文的文献

1
A comparison of behavioural effects and morphological features of grafts rich in cholinergic neurons placed in two sites of the denervated rat hippocampus.置于去神经大鼠海马两个部位的富含胆碱能神经元移植物的行为效应和形态学特征比较。
Exp Brain Res. 1996 Sep;111(2):187-207. doi: 10.1007/BF00227297.
2
Immunoidentification of cellular brain proteins associated with cognitive recovery in brain transplants.与脑移植中认知恢复相关的细胞脑蛋白的免疫鉴定
Exp Brain Res. 1994;97(3):466-70. doi: 10.1007/BF00241540.
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Nootropic effect of nicotine on carbon monoxide (CO)-induced delayed amnesia in mice.
尼古丁对一氧化碳（CO）诱导的小鼠延迟性失忆的促智作用。
Psychopharmacology (Berl). 1994 Sep;116(1):33-9. doi: 10.1007/BF02244868.
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Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease.急性皮下注射尼古丁对阿尔茨海默病患者注意力、信息处理及短期记忆的影响
Psychopharmacology (Berl). 1992;108(4):485-94. doi: 10.1007/BF02247426.