Department of Anesthesiology, Penn State Hershey, PO Box 850, Hershey, PA 17033, USA.
Best Pract Res Clin Anaesthesiol. 2012 Jun;26(2):117-30. doi: 10.1016/j.bpa.2012.01.003.
The latest generation of ventricular assist devices has evolved from the pulsatile, volume-displacement pumps of the 1990s to today's non-pulsatile, constant pressure-generating rotary pumps. These pumps include both centrifugal and axial flow devices that are currently being used or are in advanced development. Rotary pumps have the advantage of a much longer and more reliable duty life than pulsatile pumps. They are also considerably smaller than pulsatile pumps, requiring less invasive surgery for implantation and smaller transcutaneous (electrical rather than pneumatic) drivelines. Most of these devices have been approved as a bridge to transplant (BTT) while some are currently in trials for destination therapy (DT) in Europe (Conformité Européenne (CE) mark) or the United States (Food and Drug Administration (FDA)). This article discusses the current generation of pumps, examining particular design features as highlighted by the designers as well as the current approval status of each device in the United States and Europe.
最新一代心室辅助装置已经从 20 世纪 90 年代的脉动、容积置换泵发展到今天的非脉动、恒压产生的旋转泵。这些泵包括目前正在使用或正在进行高级开发的离心式和轴流式装置。旋转泵的优点是比脉动泵具有更长、更可靠的工作寿命。它们也比脉动泵小得多，植入所需的手术侵入性更小，经皮（电而不是气动）驱动线更小。这些设备中的大多数已被批准作为移植桥（BTT），而一些目前正在欧洲（欧洲符合性 (CE) 标志）或美国（食品和药物管理局 (FDA)）进行用于终末期心力衰竭的治疗（DT）试验。本文讨论了当前一代的泵，检查了设计者强调的特定设计特点以及每种设备在美国和欧洲的当前批准状态。
