Department of General Practice and Family Medicine, Center for Public Health, Medical University of Vienna, Austria.
Eur J Epidemiol. 2012 Sep;27(9):729-38. doi: 10.1007/s10654-012-9724-4. Epub 2012 Aug 22.
Restricted fetal growth and young maternal age have been associated with increased risk of suicidal behaviour later in life. Research investigating the independent and interacting effects of these risk factors with parental mental health and socio-economic status is scarce. A case-control study was effected through record linkage between Swedish registers. Individuals born 1973-1983 who were hospitalized due to a suicide attempt (n = 17,159) or committed suicide (n = 1,407) were matched to ≤10 controls by sex, month and county of birth. Controlling for parental conditions, significantly increased odds ratios (OR) for suicide attempt were found for low birth weight (OR = 1.12, 95 % CI 1.01-1.25), short birth length (OR = 1.15, 95 % CI 1.08-1.22), short and light for gestational age (OR = 1.23, 95 % CI: 1.10-1.38), short but not light for gestational age (OR = 1.18, 95 % CI: 1.09, 1.29), teenage motherhood (OR = 1.66, 95 % CI 1.53-1.80), young fatherhood (OR = 1.33, 95 % CI 1.27-1.39) and multiparity (OR = 1.40, 95 % CI 1.31-1.50). For completed suicide, increased odds ratios were found for low birth weight (OR = 1.65, 95 % CI 1.16-2.35), teenage motherhood (OR = 1.44, 95 % CI 1.09-1.90) and young fatherhood (OR = 1.20, 95 % CI 1.02-1.41). There was a synergy effect between teenage motherhood and parental psychiatric inpatient care with regard to suicide attempt in offspring [synergy index = 1.53 (95 % CI 1.27-1.84)]. Low birth weight and length, and short and light for gestational age may increase the risk of subsequent suicidal behaviour, and more research is needed to investigate underlying mechanisms. Public health implications from this study include measures to improve pre- and perinatal parental mental health, particularly in teenage pregnancies.
胎儿生长受限和母亲年龄较小与日后自杀行为的风险增加有关。研究调查这些风险因素与父母心理健康和社会经济地位的独立和相互作用的影响还很稀缺。通过瑞典登记册的记录链接进行了病例对照研究。因自杀企图而住院的个体（n=17159）或自杀（n=1407）于 1973-1983 年出生，按性别、月份和出生县与≤10 名对照相匹配。在控制父母状况的情况下，低出生体重（OR=1.12，95%CI1.01-1.25）、出生体长短（OR=1.15，95%CI1.08-1.22）、早产且体重轻（OR=1.23，95%CI：1.10-1.38）、早产但体重不轻（OR=1.18，95%CI：1.09，1.29）、母亲未成年（OR=1.66，95%CI1.53-1.80）、父亲未成年（OR=1.33，95%CI1.27-1.39）和多胎妊娠（OR=1.40，95%CI1.31-1.50）与自杀未遂的几率比值显著增加。对于自杀死亡，低出生体重（OR=1.65，95%CI1.16-2.35）、母亲未成年（OR=1.44，95%CI1.09-1.90）和父亲未成年（OR=1.20，95%CI1.02-1.41）的几率比值增加。母亲未成年和父母精神科住院治疗之间存在自杀未遂的协同效应[协同指数=1.53（95%CI1.27-1.84）]。低出生体重和长度，以及早产且体重轻可能会增加日后自杀行为的风险，需要进一步研究以调查潜在机制。这项研究的公共卫生意义包括采取措施改善产前和围产期父母的心理健康，特别是在青少年怀孕的情况下。
