[水刀切割炎症滑膜组织的体外研究]

[In-vitro study on dissection of inflamed synovial tissue by hydro-jet cutting].

作者信息

Wagner K-H, Tarner I H, Lange U

机构信息

Universitätshautklinik, UKGM Gießen, Gießen, Deutschland.

出版信息

Z Rheumatol. 2012 Oct;71(8):707-10. doi: 10.1007/s00393-012-1010-z.

DOI:10.1007/s00393-012-1010-z

PMID:22911435

Abstract

Surgical synovectomy is a useful therapeutic option for rheumatoid arthritis patients with ongoing active synovitis despite optimal medical therapy. The present experimental study evaluated the novel, minimally invasive surgical technique of hydro-jet cutting in vitro using synovial biopsies. Depending on the selected water pressure (30-100 bar) it is possible to achieve precise and selective dissection of the synovial membrane. It was found that application of a water jet at 60 bar for 15 s is ideal for dissecting the stratum synoviale from the stratum fibrosum without any alteration of the joint capsule. This finding was confirmed by histological analyses. This novel and precise dissection technique promises to be an excellent alternative to the established techniques of synovectomy in the near future.

摘要

对于尽管接受了最佳药物治疗但仍存在持续性活动性滑膜炎的类风湿关节炎患者，手术滑膜切除术是一种有效的治疗选择。本实验研究使用滑膜活检在体外评估了新型微创水刀切割手术技术。根据所选水压（30 - 100巴），可以实现滑膜的精确和选择性分离。结果发现，在60巴水压下施加水刀15秒最适合从纤维层分离滑膜层，且不会对关节囊造成任何改变。这一发现得到了组织学分析的证实。这种新颖且精确的分离技术有望在不久的将来成为既定滑膜切除技术的极佳替代方法。